Abstract
Objective:To explore the types of pathogenic bacteria composition and drug resistance in wound infections in orthopedic patients,providing guidance for the rational use of antimicrobial drugs in clinical practice.Methods:A total of 200 patients with wound infections in the orthopedics department of Anfu County People's Hospital from January 2020 to December 2022 were selected for the study.Secretions from the infection sites of all study subjects were collected as research specimens,subjected to isolation and cultivation,identification of pathogenic microorganisms,and analysis of their drug resistance.The final test results were statistically analyzed.Results:320 strains of pathogenic microorganisms were isolated,with Gram-positive bacteria,Gram-negative bacteria,and fungi accounting for 44.06%,53.44%,and 2.50%,respectively.Among Gram-positive bacteria,Staphylococcus aureus had a 0.00%resistance rate to vancomycin and a 1.61%resistance rate to linezolid.Penicillin,clindamycin,erythromycin,and other drugs showed relatively high resistance rates against Staphylococcus aureus,especially penicillin,with a resistance rate of 100.00%.Coagulase-negative staphylococci had a 0.00%resistance rate to both vancomycin and linezolid.For Coagulase-negative staphylococci,resistance rates to levofloxacin,ciprofloxacin,gentamicin,penicillin,clindamycin,erythromycin,and other drugs were also relatively high,especially penicillin,with a resistance rate of 100.00%.Among Gram-negative bacteria,Pseudomonas aeruginosa had relatively low resistance rates to ceftazidime/sulbactam,amikacin,tazobactam/piperacillin,meropenem,and imipenem,some even being 0.00%.Escherichia coli had relatively low resistance rates to ceftazidime/sulbactam,tazobactam/piperacillin,meropenem,and imipenem,but higher resistance rates to ampicillin,cefoxitin,and cephalothin.Klebsiella pneumoniae had relatively low resistance rates to ceftazidime/sulbactam,tazobactam/piperacillin,meropenem,and imipenem,but higher resistance rates to ampicillin,cefoxitin,and cephalothin.Conclusion:The causes of orthopedic wound infections are diverse,and the pathogenic microorganisms involved are complex.Therefore,rapid identification of pathogenic microorganisms and drug sensitivity testing are crucial in clinical practice.Rational selection of antibiotics based on drug sensitivity testing results can help reduce the emergence of multidrug-resistant strains and accelerate the patient's recovery process.关键词
骨科/感染/伤口/病原菌检验/金黄色葡萄球菌Key words
Orthopedics/Infection/Wound/Pathogenic microorganism test/Staphylococcus aureus分类
医药卫生
