中国伤残医学2024，Vol.32Issue(10)：10-12,16,4.DOI:10.13214/j.cnki.cjotadm.2024.010.003
布鲁氏菌病致骨关节损伤患者骨关节功能障碍评分与血清抗体检测指标的相关性研究
Study on Correlation Between Bone and Joint Dysfunction Score and Serum Antibody Detection Index in Patients with Bone and Joint Injury Caused by Brucellosis
王兵义 1刘伟国 2任杰 3李红梅 1马中瑞4
作者信息
- 1. 民勤县疾病预防控制中心卫生检验科,甘肃 武威 733399
- 2. 民勤县疾病预防控制中心卫生监测科
- 3. 民勤县疾病预防控制中心地方病防治科
- 4. 民勤县人民医院骨科
- 折叠
摘要
Abstract
Objective:To study the correlation between bone and joint dysfunction score and serum antibody detection index in patients with bone and joint injury caused by brucellosis.Methods:44 patients with bone and joint injury caused by brucellosis who were tested in our center from May 2020 to April 2023 were selected as the brucellosis group,and 44 healthy people without brucellosis infection who were tested in our center during the same period were selected as the control group.Osteoarthritis function Score-Japanese Orthopaedic Association(JOA)score was used to evaluate the osteojoint dysfunction of patients in both groups.Meanwhile,serum was sent to County People's Hospital to detect the levels of anti-cyclic guanidine polypeptide antibodies and anti-type Ⅱ collagen,and correlation analysis was conducted.Results:The bone and joint JOA score of brucellosis group was significantly lower than that of control group,and the difference between groups was statistically significant(P<0.05).The serum anti-cyclic guanidine polypeptide antibody and anti-typeⅡ collagen contents in brucellosis group were significantly higher than those in control group,with statistical significance(P<0.05).Pearson analysis in the brucellosis group showed that there was a correlation between the bone and joint JOA score and the serum anti-cyclic agglutinine polypeptide antibody and anti-type Ⅱ collagen content in the patients with brucellosis(P<0.05).In the brucellosis group,the bone and joint JOA score were used as the dependent variable,and serum anti-cyclic guanidine polypeptide antibody and anti-typeⅡcollagen content were used as independent variables.Multiple logistic regression analysis showed that,Serum anti-cyclic guanidine polypeptide antibody and anti-type Ⅱ collagen content were important factors affecting bone and joint JOA score in patients with bone and joint injury caused by brucellosis(P<0.05).Conclusion:The bone and joint injury caused by brucellosis is often accompanied by the high expression of anti-cyclic guanidine polypeptide antibody and anti-type Ⅱ collagen protein in serum.There is a correlation between the bone and joint dysfunction score and serum antibody detection index in patients with brucellosis.关键词
布鲁氏菌病/骨关节损伤/骨关节功能障碍评分/抗环状胍氨酸多肽抗体/抗Ⅱ型胶原蛋白/相关性Key words
Brucellosis/Bone and joint injury/Bone and joint dysfunction score/Anti-cyclic guanine polypeptide antibody/Anti-type Ⅱ collagen/Correlation分类
医药卫生引用本文复制引用
王兵义,刘伟国,任杰,李红梅,马中瑞..布鲁氏菌病致骨关节损伤患者骨关节功能障碍评分与血清抗体检测指标的相关性研究[J].中国伤残医学,2024,32(10):10-12,16,4.
