不同范围的INR对应用华法林的老年患者的影响OA

Objective:To explore the effects of different ranges of INR on elderly patients treated with warfarin,its clinical efficacy and safety.Methods:100 elderly patients with nonvalvular atrial fibrillation hospitalized in our hospital from January 2019 to December 2020 were selected as the study objects and randomly divided into a control group and a study group,with 50 cases in each group.The INR of the control group was maintained at 1.6～2.0,and the INR of the study group was maintained at 2.1～2.6.The warfarin dose was adjusted according to the INR value.The INR of each group was monitored once a week before reaching the target value.The INR was monitored every 4 weeks after stabilization.The clinical efficacy and incidence of adverse events such as bleeding embolization were observed and compared between the two groups.Results:There was no significant difference in the occurrence of hemorrhage between the two groups(P>0.05).The incidence of adverse events and the level of NT-proBNP in the study group were significantly lower than those in the control group(P<0.05).Conclusion:When INR is controlled in the range of 2.1～2.6,it can prevent clinical embolism and other adverse events in elderly patients with NVAF,protect vascular endothelium to prevent thrombosis,and further improve the cardiac function of patients.