摘要
Abstract
Objective:To investigate the therapeutic effect of compound Xianlinggubao capsule on patients with osteoporotic vertebral compression fracture.Methods:86 patients with osteoporotic vertebral compression fracture in our hospital from January 2020 to October 2022 were selected as research objects and divided into a control group and an observation group according to random number table method,with 43 cases in each group.The control group was treated with percutaneous vertebrae formation(PVP)combined with conventional anti-osteoporosis treatment,and the observation group was treated with Compound Xianling Gubao Capsule on the basis of the control group.The therapeutic effects of the two groups were compared.Results:Before treatment,there were no significant differences in tartrate-resistant acid phosphatase(5bTRAP-5b),carboxy-terminal cross-linked peptide(CTx)of type 1 collagen and bone mineral density(BMD)between 2 groups(P>0.05).After treatment,TRAP-5b in 2 groups was lower than before treatment,and the observation group was lower than the control group,the CTX、BMD were higher than before treatment,and the observation group were higher than the control group,and the difference between groups was statistically significant(P<0.05).There was no statistically significant difference in VAS score between the two groups before treatment(P>0.05),VAS score of the two groups decreased after 1 month,3 months and 6 months,and the observation group was lower than the control group,the incidence of chronic pain in the observation group was significantly lower than the control group,and the difference between the two groups was statistically significant(P<0.05).Before treatment,there were no statistical significance in spinal Function Index Scale(SFI)and Japanese Orthopaedic Association(JOA)scores between the two groups(P>0.05).After treatment,SFI and JOA scores of the two groups were higher than before treatment,and the observation group was higher than the control group,with statistical significance between the two groups(P<0.05).There was no significant difference in the occurrence of adverse conditions between the two groups(P>0.05).Conclusion:Adding compound Xianling Gubao capsule to the treatment of osteoporotic vertebral compression fracture on the basis of conventional treatment can improve the level of bone metabolism and bone mineral density,reduce postoperative pain and the incidence of chronic pain,and improve the spinal and lumbar function of patients with high safety.关键词
复方仙灵骨葆胶囊/骨质疏松/椎体压缩骨折/疼痛/骨密度Key words
Compound Xianling Gubao Capsule/Osteoporosis/Vertebral compression fracture/Pain/Bone mineral density分类
医药卫生
