四川中医2024，Vol.42Issue(6)：59-63,5.
基于"脂毒"说探讨高脂饮食对肠道干细胞的影响在肠道疾病中的发病作用及防治思路
Based on the theory of'lipid toxin',to explore the effect of high fat diet on intestinal stem cells in the pathogenesis and prevention of intestinal diseases
摘要
Abstract
Studies on pathogenesis related to high fat diet tend to focus on cardiovascular diseases and endocrine diseases,etc.However,there are relatively few studies on the gut as an organ in direct contact.In recent years,relevant studies have found that the influence of high fat diet on intestinal stem cells(ISC)is also closely related to the incidence of intestinal diseases.In this paper,from the perspective of'lipid toxin'theory,we discussed the effect of high-fat diet on ISC in the pathogenesis of in-testinal diseases.Firstly,the intestinal microecology was damaged and the metabolic environment of ISC was changed.Secondly,the increase of bile acid level induced ISC endoplasmic reticulum stress involved in ISC functional impairment.In the three cases,phlegm formation and stasis made the cancer endophytic and enhanced the dry and tumorigenic nature of ISC.From this perspec-tive,new ideas for the prevention and treatment of intestinal diseases can be provided:prevention should precede treatment,and Sun Simiao's'Light food'diet regimen should be followed;Secondly,the above mentioned spleen-strengthening treatment is used to regulate intestinal microecology and improve ISC metabolic environment.Second,restore liver drainage to improve bile acid metabolism and maintain the homeostasis of ISC endoplasmic reticulum.Three should be expectorant and stasis,reduce ISC tumorigenicity.关键词
膏粱之味/脂毒/肠道干细胞(ISC)/防治Key words
rich food/lipid toxin/intestinal stem cells(ISC)/prevention and treatment分类
医药卫生引用本文复制引用
陈思琪,张馨丹,朱焰,田思雨,陈敏..基于"脂毒"说探讨高脂饮食对肠道干细胞的影响在肠道疾病中的发病作用及防治思路[J].四川中医,2024,42(6):59-63,5.基金项目
国家自然科学基金项目(编号:82274529). （编号:82274529）
