基于"脂毒"说探讨高脂饮食对肠道干细胞的影响在肠道疾病中的发病作用及防治思路OACSTPCD

Studies on pathogenesis related to high fat diet tend to focus on cardiovascular diseases and endocrine diseases,etc.However,there are relatively few studies on the gut as an organ in direct contact.In recent years,relevant studies have found that the influence of high fat diet on intestinal stem cells(ISC)is also closely related to the incidence of intestinal diseases.In this paper,from the perspective of'lipid toxin'theory,we discussed the effect of high-fat diet on ISC in the pathogenesis of in-testinal diseases.Firstly,the intestinal microecology was damaged and the metabolic environment of ISC was changed.Secondly,the increase of bile acid level induced ISC endoplasmic reticulum stress involved in ISC functional impairment.In the three cases,phlegm formation and stasis made the cancer endophytic and enhanced the dry and tumorigenic nature of ISC.From this perspec-tive,new ideas for the prevention and treatment of intestinal diseases can be provided:prevention should precede treatment,and Sun Simiao's'Light food'diet regimen should be followed;Secondly,the above mentioned spleen-strengthening treatment is used to regulate intestinal microecology and improve ISC metabolic environment.Second,restore liver drainage to improve bile acid metabolism and maintain the homeostasis of ISC endoplasmic reticulum.Three should be expectorant and stasis,reduce ISC tumorigenicity.