溃疡性结肠炎中医辨证分型与血清pANCA、IL-23水平及疾病严重程度的相关性研究OACSTPCD
Study on the correlation between TCM syndrome differentiation and the level of pANCA,IL-23and the severity of ulcerative colitis
目的:探究溃疡性结肠炎中医辨证分型与血清核周型抗中性粒细胞质抗体(pANCA)、白介素-23(IL-23)水平及疾病严重程度的相关性.方法:回顾性选取我院2021年1月～2023年6月收治的278例溃疡性结肠炎患者为研究对象,分析患者的临床资料并将纳入的患者进行中医辨证分型.收集所有患者的血清pANCA、IL-23水平;采用Mayo活动性分级评估患者的疾病严重程度分级.通过单因素分析、Pearson相关性分析等方法进行统计分析.结果:278例溃疡性结肠炎患者中,大肠湿热证131例(47.12％),脾肾阳虚证99例(35.61％),血瘀肠络证48例(17.27％).三种中医辨证分型患者的Mayo活动性评分、血清pANCA、IL-23水平进行比较,差异有统计学意义(P＜0.05).根据Mayo活动性评分将患者分为轻度活动期、中度活动期和重度活动期三种疾病严重程度,共分得轻度活动期116例、中度活动期96例和重度活动期66例,其中轻度活动期主要以脾肾阳虚证为主,中度活动期以大肠湿热证为主(P＜0.05),重度活动期例数则无明显差异(P＞0.05).三种疾病严重程度患者的pANCA、IL-23水平呈重度活动期＞中度活动期＞轻度活动期趋势,差异有统计学意义(P＜0.05).Pearson相关性分析结果显示,血清pANCA、IL-23水平与Mayo活动性评分呈正相关性(P＜0.05).结论:溃疡性结肠炎中医辨证分型与血清pANCA、IL-23水平及疾病严重程度具有一定的关系,临床可根据血清pANCA、IL-23水平及疾病严重程度来判断溃疡性结肠炎患者的中医辨证分型.
Objective To explore the correlation between TCM syndrome differentiation and the levels of serum perinuclear anti-neutrophilic antibody(pANCA)and interleukin-23(IL-23)and the severity of ulcerative colitis.Methods 278patients with ulcerative colitis admitted to our hospital from January 2021to June 2023were retrospectively selected as the study objects,the clinical data of the patients were analyzed,and the included patients were classified by TCM syndrome differentiation.pANCA and IL-23levels were collected from all patients.Mayo activity scale was used to evaluate the severity of disease.Single factor a-nalysis and Pearson correlation analysis were used for statistical analysis.Results Among 278patients with ulcerative colitis,there were 131cases(47.12％)of large intestine damp-heat syndrome,99cases(35.61％)of spleen and kidney Yang deficiency syn-drome,and 48cases(17.27％)of blood stasis and intestinal collateral syndrome.The Mayo activity score,serum pANCA and IL-23levels of the three TCM syndrome differentiation types were compared,and the differences were statistically significant(P＜0.05).According to the Mayo activity score,the patients were divided into three types of disease severity:mild active stage,moderate active stage and severe active stage.A total of 116cases were mildly active stage,96cases were moderately active stage and 66cases were severely active stage.The mild active stage was dominated by spleen-kidney Yang deficiency syndrome,the moderate active stage was dominated by large intestine damp-heat syndrome(P＜0.05),and the number of cases in severe ac-tive stage was not significantly different(P＞0.05).Pearson correlation analysis showed that serum pANCA and IL-23levels were positively correlated with Mayo activity score(P＜0.05).Conclusion There is a certain relationship between TCM syndrome dif-ferentiation and serum pANCA,IL-23level and disease severity.The TCM syndrome differentiation and classification of ulcerative colitis patients can be judged clinically according to serum pANCA,IL-23level and disease severity.
陈小刚;李霞;刘小敏
昆山市中西医结合医院脾胃病科,江苏昆山 215300九江市中医医院脾胃病科,江西九江 332000
临床医学
溃疡性结肠炎中医辨证分型核周型抗中性粒细胞胞浆抗体白介素-23Mayo活动性分级
ulcerative colitisTCM syndrome differentiation and classificationPerinuclear anti-neutrophil cytoplasmic an-tibodyInterleukin-23Mayo activity scale
《四川中医》 2024 (006)
84-87 / 4
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