骨质疏松症患者PINP、25-(OH)VitD3、BMP-2与中医辨证分型的相关性研究OACSTPCD

Objective To analyze the correlation between serum total type Ⅰ collagen amino terminal propeptide(PINP),25-hydroxyvitamin D3[25-(OH)VitD3],bone morphogenetic protein 2(BMP-2)and TCM syndrome differentiation in patients with osteoporosis.Methods The general data and TCM four diagnostic data of 157patients with osteoporosis admitted to the hospital from August 2020to August 2023were retrospectively analyzed,and the results of TCM syndrome differentiation of osteoporosis pa-tients were counted.The basic data,PINP,25-(OH)VitD3 and BMP-2levels of patients with different syndromes were com-pared.Results There were 34cases of kidney yang deficiency syndrome,43cases of spleen and kidney yang deficiency syndrome,49cases of liver and kidney yin deficiency syndrome,and 31cases of blood stasis and qi stagnation syndrome in 157patients with osteoporosis.The levels of serum PINP,25-(OH)VitD3 and BMP-2in osteoporosis patients with different TCM syndrome types were statistically significant(P＜0.05).Among them,the level of PINP in the blood stasis and qi stagnation group was signifi-cantly higher than that in the kidney yang deficiency group,the spleen and kidney yang deficiency group and the liver and kidney yin deficiency group(P＜0.05),while there was no significant difference between the other three groups(P＞0.05).The level of 25-(OH)VitD3 in patients with spleen and kidney yang deficiency syndrome was significantly lower than that in kidney yang deficiency group,liver and kidney yin deficiency group and blood stasis and qi stagnation group(P＜0.05),and the kidney yang deficiency group was lower than that in liver and kidney yin deficiency group and blood stasis and qi stagnation group(P＜0.05),while there was no significant difference between the other two groups(P＞0.05).The level of BMP-2in blood stasis and qi stag-nation group was significantly lower than that in kidney yang deficiency group,spleen and kidney yang deficiency group and liver and kidney yin deficiency group(P＜0.05).The results of binary logistic regression analysis showed that blood stasis and qi stag-nation were positively correlated with PINP(P＜0.05)and negatively correlated with BMP-2(P＜0.05).Spleen-kidney yang deficiency was negatively correlated with 25-(OH)VitD3(P＜0.05).Conclusion The levels of serum PINP,25-(OH)VitD3 and BMP-2in patients with osteoporosis have a certain correlation with TCM syndrome differentiation,which can be used as a reference index to evaluate the TCM syndrome differentiation of patients.