摘要
Abstract
ObjectiveTo explore the clinical efficacy of modified self-made Jianpi Yangwei decoction in the treatment of gas-tric cancer and its influence on TCM syndromes scores,serum pepsinogen Ⅰ(PGⅠ)and pepsinogen Ⅱ(PGⅡ).Methods Accord-ing to the simple randomization grouping method,patients with advanced primary gastric cancer of spleen-stomach deficiency-cold type from January 2021 to January 2023were divided into observation group and control group,with 60cases in each group.The control group received conventional chemotherapy while the observation group was treated with modified self-made Jianpi Yangwei decoction,and both groups were continuously treated for 6months.The clinical efficacy and occurrence of toxic and side effects after 6months of treatment and TCM syndromes scores,gastrointestinal hormones[PGⅠ,PGⅡ,gastrin(GAS)],tumor markers[carbohydrate antigen 19～9(CA19～9),carbohydrate antigen 72～4(CA72～4),carcinoembryonic antigen(CEA)]and quality of life[Quality of Life Assessment Instrument for Gastric Cancer(QLASTCM-Ga)]before treatment and after 6months of treatment were compared between both groups of patients.Results The total effective rate in observation group was significantly higher than that in control group(P＜0.05).The observation group had significantly lower incidence rates of toxic and side effects(P＜0.05).After 6months of treatment,the TCM syndromes scores,levels of CA19～9,CA72～4and CEA and QLASTCM-Ga scores in the two groups were significantly reduced compared with those before treatment,and the scores and lev-els in observation group were lower(all P＜0.05).The levels of PGⅠ,PGⅡ and GAS were significantly enhanced in the two groups than those before treatment,and the levels in observation group were higher compared to control group(all P＜0.05).Conclusion Modified self-made Jianpi Yangwei decoction can effectively treat patients with gastric cancer of spleen-stomach defi-ciency-cold type,and can significantly improve the TCM syndromes scores,gastrointestinal hormones,tumor markers and quality of life,and reduce the occurrence of toxic and side effects.关键词
健脾养胃汤/加味/胃癌/临床疗效/中医证候积分/血清PGⅠ/PGⅡKey words
Jianpi Yangwei decoction/Modified/Gastric cancer/Clinical efficacy/TCM syndromes scores/Serum PGⅠ/PGⅡ分类
医药卫生
