加味半夏白术天麻汤联合阿司匹林肠溶片治疗偏头痛患者对头痛症状及血浆5-HT,VEGF,CGRP的影响OACSTPCD

Objective:To explore the effects of added Banxia Baizhu Tianma Decoction combined with aspirin enteric-coated tablets on headache symptoms,plasma 5-hydroxytryptamine(5-HT),vascular endothelial growth factor(VEGF)and calcitonin gene-related peptide(CGRP)in migraine patients.How:A total of 120migraine patients admitted to our hospital from April 2020to April 2022were grouped according to random number table method.In the control group,60cases were treated with aspirin enteric-coated tablets,and in the study group,60cases were treated with added Banxia Baizhu Tianma Decoction combined with aspirin enteric-coated tablets.To evaluate the clinical efficacy of the two groups,compare the levels of headache,plasma 5-HT,VEGF,CGRP and inflammatory factors before and after treatment between the two groups,and observe the adverse reactions of the two groups.Result:The total effective rate of the study group was higher than that of the control group(P＜0.05).After treat-ment,the headache symptoms of the study group were significantly relieved compared with the control group(P＜0.05).After treatment,the levels of VEGF,CGRP,interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)in the study group were lower than those in the control group,and the levels of 5-HT were higher than those in the control group(P＜0.05).The incidence of adverse reactions in the study group was lower than that in the control group(P＜0.05).Con-clusion:Added Banxia Baizhu Tianma Decoction combined with aspirin enteric-coated tablets has significant efficacy and high safety in the treatment of migraine patients,which can effectively relieve the headache symptoms of patients,regulate the levels of plasma 5-HT,VEGF and CGRP,and reduce the levels of inflammatory factors.