摘要
Abstract
Objective To observe the efficacy of Wenyang Shufeng decoction combined with levocetirizine in the treatment of chronic urticaria and its effect on serum monocyte chemoattractant protein(MCP)and lung activation regulating chemokine/che-mokine ligand 18(PARC/CCL-18)in the treatment of chronic urticaria.Methods 130patients with chronic urticaria admitted in our hospital in October 2020～May 2023were divided into two groups according to the treatment method,65cases in each group.The control group was treated with levoxetirizine,and the observation group was treated with Wenyang Shufeng decoction com-bined with levoxetirizine.The scores of quality of life index(DLQI)and the changes of Th1/Th2factors and MCP、PARC/CCL-18were recorded groups were recorded.Results A total effective rate of 95.38％in the observation group was higher than that in the control group(P＜0.05).Two groups of interferon-γ(IFNγ)increased after treatment(P＜0.05),Monocyte chemoattrac-tant protein-1(MCP-1),monocyte chemoattractant protein-3(MCP-3),PARC/CCL-18,interleukin-4(IL-4),tumor necrosis factor-α(TNF-α),interleukin-10(IL-10)decreased compared to pre-treatment(P＜0.05),The IFN-γ in the ob-servation group was higher than that in the control group(P＜0.05)and the MCP、PARC/CCL-1、IL-4、TNF-α、IL-10was lower than that in the control group(P＜0.05).The DLQI scores of the two groups(including symptoms and feelings,interper-sonal relationships,leisure activities,daily activities,work and study,and clinical treatment)decreased after treatment(P＜0.05),and the DLQI scores of the observation group were lower than those of the control group(P＜0.05).Compared with the two groups,there was no statistical significance(P＞0.05).Conclusion Wenyang Shufeng decoction combined with levoxetirizine in the treatment of chronic urticaria can improve the efficacy and quality of life,which may be related to the expression of Th1/Th2factors and MCP、PARC/CCL-18.关键词
温阳疏风汤/左西替利嗪/慢性荨麻疹/单核细胞趋化蛋白/生活质量Key words
Warm Yang Shufeng Tang/Levocetirizine/Chronic urticaria/Monocyte chemoattractant protein/Quality of life分类
医药卫生
