药学研究2024，Vol.43Issue(6)：554-558,5.DOI:10.13506/j.cnki.jpr.2024.06.006
UHPLC-Q-Orbitrap HRMS技术用于法莫替丁有关物质的结构解析
Structural identification of related substances of Famotidine by UHPLC-Q-Orbitrap HRMS
摘要
Abstract
Objective To identify the related substances of Famotidine.Methods According to Xcalibar and Mass Frontier software,the related substances of Famotidine were detected by ultra high performance liquid chromatography-quadrupole/electrostatic field orbitrap high resolution mass spectrometry(UHPLC-Q-Orbitrap HRMS).Results Three related substances were identified by UHPLC-Q-Orbitrap HRMS.Conclusion The established UHPLC-Q-Orbitrap HRMS method is effective for the identification of the related substances of Famotidine,which is of great useful for its optimization of production process and quality control.关键词
法莫替丁/有关物质/高分辨质谱/结构解析Key words
Famotidine/Related substances/HRMS/Structure identification分类
药学引用本文复制引用
李文馨,张连义,王雪,郭常川,杨书娟,徐玉文..UHPLC-Q-Orbitrap HRMS技术用于法莫替丁有关物质的结构解析[J].药学研究,2024,43(6):554-558,5.基金项目
国家自然科学基金项目(No.81573606、81973486) （No.81573606、81973486）
泰山产业领军人才工程专项经费(No.tscx202306073) （No.tscx202306073）
