药学研究2024，Vol.43Issue(6)：573-578,6.DOI:10.13506/j.cnki.jpr.2024.06.010
神经系统相关疾病药物治疗新靶点:Hv1
A new target for drug therapy of neurological diseases:Hv1
摘要
Abstract
Voltage-gated proton channel(Hv1)is a highly proton selective channel that is expressed and performs physiological functions in nervous system.Hv1 regulates cytosolic pH and participates in the production NOX-dependent reactive oxygen species by transporting protons across membranes,and then plays a role in the regulation of neurological diseases.This review summarized the expression and distribution of Hv1 in the nervous system and the regulation of neurological diseases.关键词
电压门控质子通道/质子/活性氧/神经系统相关疾病Key words
Hv1/Protons/Reactive oxygen species/Neurological diseases分类
临床医学引用本文复制引用
缪路荣,李光,张广钦..神经系统相关疾病药物治疗新靶点:Hv1[J].药学研究,2024,43(6):573-578,6.基金项目
国家自然科学基金(No.81870261) （No.81870261）
