实验动物与比较医学2024，Vol.44Issue(3)：289-296,8.DOI:10.12300/j.issn.1674-5817.2023.183
长骨骨折动物模型的研究进展
Research Progress on Animal Models of Long Bone Fractures
摘要
Abstract
Traumatic fractures and stress fractures are common orthopedic diseases,and there is great potential in researching bone turnover,repair,and promotion of fracture healing.Basic medical experiments often use animal models of long bone fractures in limbs to study the mechanisms of various interventions on fracture healing.Fracture healing is a complex process influenced by multiple factors and involves multiple molecules and pathways.Therefore,to explore the mechanisms more deeply,accelerate the translation of results,and improve the clinical efficacy,it is particularly important to choose the appropriate animal fracture modeling methods in experimental research.Based on this,this paper conducts a literature review of animal species and modeling methods commonly used for long bone fracture models in experimental research.It summarizes five methods:bone defect method,physical impact method,mechanical bending method,open osteotomy method,and drilling method.A side-by-side comparison of their advantages,disadvantages,and scope of application is made,aiming to provide suitable fracture models for studyingthe mechanisms of fracture healing interventions.关键词
动物模型/骨折愈合/长骨Key words
Experimental animal model/Fracture healing/Long bone分类
医药卫生引用本文复制引用
姚广源,董平,吴昊,柏梅,党赢,王悦,胡凯..长骨骨折动物模型的研究进展[J].实验动物与比较医学,2024,44(3):289-296,8.基金项目
内蒙古自治区高等学校科学研究项目"基于TGF-β/BMPs信号通路探讨李氏接骨散对家兔骨折愈合的影响"(NJZY20135) （NJZY20135）
内蒙古医科大学科技创新团队计划"骨与关节疾病中医药防治科技创新团队"(YKD2022TD033) （YKD2022TD033）
内蒙古自治区直属高校研究生卓越人才项目计划"基于TGF-β/Smad信号通路探讨李氏接骨散对大鼠骨折愈合的影响"(YKD2023ZY001) （YKD2023ZY001）
