实验动物与比较医学2024，Vol.44Issue(3)：305-312,8.DOI:10.12300/j.issn.1674-5817.2023.181
SPF鸡的主要垂直传播性病原体及其检测标准分析
Analysis of Major Vertically Transmissible Pathogens and Their Detection Standards in SPF Chickens
摘要
Abstract
Specific pathogen-free(SPF)chickens are widely used in the research of avian diseases and vaccines.Vertically transmissible diseases are transmitted to chickens through vertical transmission,seriously affecting their survival rate,increasing production costs,and causing significant economic losses to the poultry industry,while severely impacting the breeding and use of SPF chickens.Therefore,it is crucial for researchers and managers to enhance their understanding of vertically transmissible pathogens in chickens and to develop effective monitoring measures.Quality monitoring is an important part of ensuring the quality of SPF chickens,with pathogen detection being the primary step.Based on this,it is necessary to cultivate qualified SPF chickens through purification methods and biosecurity measures.This paper reviews the major vertically transmissible pathogens in chickens,including viral pathogens,bacterial pathogens and mycoplasmas,as well as their detection methods.This study compares the differences in microbiological testing items and methods for SPF chickens between the U.S.corporate standard and the Chinese national standard.Analysis of the results shows that in both standards,vertically transmissible pathogens such as Escherichia coli,Proteus mirabilis,Salmonella,and avian leukosis are not included in the microbiological testing items for SPF chickens.Instead,these pathogens are characterized by mixed infections,and outbreaks can seriously affect flock health.To produce higher-quality SPF chickens,it is necessary to include these pathogens in the mandatory testing items.The aim of this paper is to help readers understand the relevant standards for microbiological monitoring of SPF chickens,the hazards of vertically transmissible pathogens,and prevention and control strategies,so as to provide a reference for the detection and purification of pathogens in SPF chickens.关键词
SPF鸡/垂直传播/病原检测Key words
SPF chickens/Vertical transmission/Pathogen detection分类
生物科学引用本文复制引用
王梦杰,马文杰,潘喻,陈见兴,张贺,夏长友,王玉娥..SPF鸡的主要垂直传播性病原体及其检测标准分析[J].实验动物与比较医学,2024,44(3):305-312,8.基金项目
十四五国家重点研发计划项目"实验动物专用设备创新研制"(2022YFF0711200) （2022YFF0711200）
