生命科学研究2024，Vol.28Issue(3)：215-222,8.DOI:10.16605/j.cnki.1007-7847.2023.05.0159
心血管纳米医学在血管平滑肌细胞中的应用
Application of Cardiovascular Nanomedicine in Vascular Smooth Muscle Cells
摘要
Abstract
Vascular smooth muscle cells(VSMCs)have the function of regulating vascular tension and main-taining vascular architecture,and their dysfunction is closely related to the onset and progression of cardio-vascular maladies.Nanomedicine refers to the application of nanomaterials in medical sciences,which is wi-dely used in the diagnosis and treatment of cardiovascular diseases,tumors and other diseases due to its abi-lity to overcome the pharmacological impediments in conventional treatment modalities,such as poor drug selectivity and low bioavailability.Based on the key roles of VSMCs in the cardiovascular system and the optimization potential of nanomedicine in the traditional drug delivery systems,this paper reviewed the pathological mechanisms of cardiovascular diseases caused by anomalous phenotypic alterations,malignant proliferation and migration of VSMCs,and summarized the utility of nanomedicine in targeting VSMC func-tions as a therapeutic strategy against cardiovascular disorders,such as targeted drug delivery,autologous therapeutic interventions,and the fabrication of tissue engineering scaffolds.The paper also discussed the imminent challenges and future trajectories of cardiovascular nanomedicine,aiming to provide potential strategies for the prevention and treatment of cardiovascular diseases.关键词
血管平滑肌细胞(VSMC)/心血管疾病/纳米医学/高血压/纳米材料Key words
vascular smooth muscle cell(VSMC)/cardiovascular disease/nanomedicine/hypertension/nano-material分类
生物科学引用本文复制引用
余玉庄,何宛欣,徐紫薇,陈金燕,郭颖欣,李华琴..心血管纳米医学在血管平滑肌细胞中的应用[J].生命科学研究,2024,28(3):215-222,8.基金项目
广东省大学生创新训练项目(基于高血压模型挖掘调控血管平滑肌细胞转换的候选基因和miRNAs)(S202113902016) （基于高血压模型挖掘调控血管平滑肌细胞转换的候选基因和miRNAs）
