实用医学杂志2024，Vol.40Issue(14)：2035-2040,6.DOI:10.3969/j.issn.1006-5725.2024.14.023
肝巨噬细胞及其可塑性特征对治疗慢加急性肝衰竭的潜在价值及研究进展
Potential value of liver macrophages and their plasticity in the treatment of ACLF
摘要
Abstract
Acute-on-chronic liver failure(ACLF)is a group of clinical syndromes related to severe acute liver function damage and multiple organ failure caused by various acute inducing factors on the basis of chronic liver disease.Due to its serious condition,rapid progression and high mortality,it has attracted more and more attention.Recent studies have shown that the pathogenesis of ACLF mainly includes direct injury and immune injury.As the main immune cells in the liver,the immunoregulatory role of liver macrophages in ACLF has been increasingly recognized.Liver macrophages have excellent phenotype conversion function and plasticity characteristics under the influence of epigenetic reprogramming or local microenvironment.This adaptive expression ability can use key mediators to promote the early conversion of anti-inflammatory phenotype to alleviate liver injury.A large number of studies have shown that liver macrophages have a certain potential in reversing the process of ACLF.Therefore,from the perspective of the plasticity characteristics of liver macrophages,this paper expounds the role of liver macrophages in ACLF and the research on the intervention of ACLF disease process,and summarizes its potential significance in the treatment of ACLF.关键词
慢加急性肝衰竭/巨噬细胞/细胞可塑性/免疫调节Key words
acute-on-chronic liver failure/macrophage/cell plasticity/immunomodulation分类
医药卫生引用本文复制引用
陈桂容,王明刚,林华明,陈鑫鑫,罗娟,叶凤琴,王秀峰..肝巨噬细胞及其可塑性特征对治疗慢加急性肝衰竭的潜在价值及研究进展[J].实用医学杂志,2024,40(14):2035-2040,6.基金项目
国家自然科学基金项目(编号:82274434) （编号:82274434）
广西自然科学基金项目(编号:2023GXNSFAA026380) （编号:2023GXNSFAA026380）
