天津中医药2024，Vol.41Issue(7)：857-864,8.DOI:10.11656/j.issn.1672-1519.2024.07.10
消癌平注射液联合一线化疗治疗晚期胃癌疗效的系统评价及Meta分析
A systematic review and Meta-analysis of the efficacy of Xiaoaiping injection combined with first-line chemotherapy in the treatment of advanced gastric cancer
摘要
Abstract
[Objective]To evaluate the efficacy and safety of Xiaoaiping injection combined with first-line chemotherapy in the treatment of advanced gastric cancer.[Methods]We searched for randomized controlled trials(RCTs)of Xiaoaiping injection combined with first-line chemotherapy regimen in the treatment of advanced gastric cancer in five Chinese and English databases published in CNKI,Wanfang Database,VIP Database,Pubmed and Web of Science,and the time range was set from the establishment of each database to October 27,2023,and the risk of bias assessment and Meta-analysis of studies that met the inclusion criteria were conducted.[Results]A total of 10 RCTs were included,including 814 patients with advanced gastric cancer,and in terms of short-term efficacy,Xiaoaiping injection combined with first-line chemotherapy regimen could improve the objective response rate(ORR)[RR:1.35,95％CI(1.15,1.58),P=0.0002]and increase the Karnofsky performance score(KPS)[RR:1.62,95％CI(1.16,2.26),P=0.005]and the number of grade 3-4 adverse events(SAEs)was lower than that of chemotherapy alone[RR:0.32,95％CI(0.06,0.90),P=0.04];in terms of long-term survival benefit,Xiaoaiping injection combined with first-line chemotherapy was significantly more effective in progression-free survival(PFS)[HR:0.32,95％CI(0.17,0.62),P=0.001]and overall survival(OS)[HR:0.33,95％CI(0.16,0.65),P=0.002]was better than chemotherapy alone,and the GRADE results showed that ORR,KPS scores,PFS,and OS were of low quality,while SAE was of very low quality.[Conclusion]Xiaoaiping injection combined with first-line chemotherapy has good clinical efficacy and safety,but the methodological quality of the included literature is low,and more comprehensive large-sample,multicenter,randomized double-blind controlled trials are needed for verification.关键词
胃癌/消癌平注射液/一线化疗/系统评价/Meta分析Key words
gastric cancer/Xiaoaiping injection/first-line chemotherapy/systematic review/Meta-analysis分类
医药卫生引用本文复制引用
匡子禹,刘可心,李杰..消癌平注射液联合一线化疗治疗晚期胃癌疗效的系统评价及Meta分析[J].天津中医药,2024,41(7):857-864,8.基金项目
国家自然科学基金面上项目(82074402) （82074402）
中国中医科学院科技创新工程重大攻关项目(CI2021A01802) （CI2021A01802）
2023年北京市重大疑难疾病中西医协同攻关项目(2023BJSZDYNJBXTGG-013). （2023BJSZDYNJBXTGG-013）
