天津中医药2024，Vol.41Issue(7)：893-897,5.DOI:10.11656/j.issn.1672-1519.2024.07.16
宣肺清络方对肺炎支原体肺炎痉挛性咳嗽大鼠肺组织病理学及炎性因子的影响
Effect of Xuanfei Qingluo Formula on lung histopathology and inflammatory factors in rats with MPP spasmodic cough
摘要
Abstract
[Objective]To investigate the mechanism of pulmonary histopathology and inflammatory factors in mycoplasma pneumoniae pneumonia(MPP)in rats with spasmodic cough.[Methods]Sixty rats were randomly divided into blank group,mycoplasma pneumoniae pneumonia group,model group,azithromycin group,Xuanfei Qingluo group,Xuanfei Qingluo+azithromycin group,a total of 6 groups.The rat model of spasmodic cough after mycoplasma pneumoniae pneumonia infection was established by nasal drops of mycoplasma pneumoniae culture+smoke method+capsaicin solution atomization,after 14 days of successful modeling,the rats in each group were given corresponding drugs by intragastric administration,after 7 days of continuous treatment,serum interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)were detected in each group.The levels of TNF-α and the pathological changes of lung tissue in each group were observed.[Results]Compared with normal group,serum expressions of IL-6,IL-8 and TNF-α were increased in mycoplasma pneumoniae pneumonia group and model group,the difference was statistically significant(P＜0.05);compared with model group,the levels of IL-6,IL-8 and TNF-α in serum of all treatment groups were significantly decreased,and the difference was statistically significant(P＜0.05);after treatment intervention,there were no significant differences in serum contents of IL-6,IL-8 and TNF-α among treatment groups(P＞0.05).[Conclusion]Xuanfei Qingluo Formula can reduce the damage of lung tissue structure and the infiltration of inflammatory cells in the interstitial.It is speculated that the mechanism may be related to the inhibition of serum inflammatory factors IL-6,IL-8 and TNF-α.关键词
肺炎支原体肺炎/宣肺清络方/炎症因子Key words
mycoplasma pneumoniae pneumonia/Xuanfei Qingluo Formula/inflammatory factor分类
医药卫生引用本文复制引用
孙越臣,张琪,刘薇薇,李亚东..宣肺清络方对肺炎支原体肺炎痉挛性咳嗽大鼠肺组织病理学及炎性因子的影响[J].天津中医药,2024,41(7):893-897,5.基金项目
国家自然科学基金项目(8200152470). （8200152470）
