天津中医药2024，Vol.41Issue(7)：939-944,6.DOI:10.11656/j.issn.1672-1519.2024.07.23
近5年推拿修复骨骼肌损伤的作用机制研究进展
Research progress on the mechanism of tuina in treating skeletal muscle injury in the past 5 years
摘要
Abstract
Common injuries such as traction,blunt trauma,and innervation injuries can cause damage to skeletal muscle.Incomplete repair is prone to scar formation,affecting muscle function.Skeletal muscle injury belongs to the category of"jinshang"in traditional Chinese medicine,and tuina,as one of the important ways of treating"j ins hang",is widely used in the treatment of skeletal muscle injury.In recent years,research on the mechanism of tuina in treating skeletal muscle injury has been widely conducted,and through the search of relevant literature,it is found that tuina can repair skeletal muscle injury through PI3K,MAPK,Notch,Wnt,and PPAR signaling pathways.Moreover,tuina focuses on muscle satellite cells,by promoting the expression of positive regulators such as myogenic regulatory factors,insulin-like growth factor,and basic fibroblast growth factor,inhibiting the expression of negative regulators such as transforming growth factor-β,growth differentiation factor-8,connective tissue growth factor,and downregulating the concentration of inflammatory factors such as tumor necrosis factor and interleukin-6,to promote muscle fiber remodeling,prevent excessive deposition of extracellular matrix,reduce inflammatory response and slow down skeletal muscle fibrosis.In addition,tuina can also promote tissue repair by promoting rational autophagy,repairing cell membranes,regulating oxidative stress,and fat metabolism.This article focuses on the repair mechanism of tuina in the treatment of skeletal muscle injury,to provide a reference for further research.关键词
骨骼肌损伤/推拿/修复/作用机制Key words
skeletal muscle injury/tuina/repair regulation/mechanism分类
医药卫生引用本文复制引用
商蔚然,李华南,李进阳,王金贵,赵娜..近5年推拿修复骨骼肌损伤的作用机制研究进展[J].天津中医药,2024,41(7):939-944,6.基金项目
国家自然科学基金项目(81973971). （81973971）
