现代医药卫生2024，Vol.40Issue(13)：2166-2173,8.DOI:10.3969/j.issn.1009-5519.2024.13.002
基于网络药理学及分子对接技术探讨过敏煎对特应性皮炎的作用机制
The mechanism of Guominjian on atopic dermatitis based on network pharmacology and molecular docking techniques
摘要
Abstract
Objective To explore the mechanism of Guominjian on atopic dermatitis(AD)based on net-work pharmacology and molecular docking techniques.Methods The active ingredients and corresponding targets of Guominjian were retrieved from TCMSP database,and AD disease related targets were obtained from OMIM,GeneCards and DrugBank database.Cytoscape3.7.2 software was used to construct the Chinese medicine component target network and STRING platform for protein interaction network analysis.GO func-tion and KEGG signal pathway database were used for enrichment analysis,active ingredient-target-pathway network was constructed,and molecular docking was performed with AutoDockVina software.Results There were 123 common targets of Guominjian and AD.GO functional enrichment analysis involved 641 items of bi-ological processes,68 items of cell components and 129 items of molecular functions.The signaling pathways including MAPK,NF-κB,TNF-α,JAK-STAT and PI3K-Akt,etc.were selected by enrichment analysis of KEGG signaling pathways.The results of molecular docking showed that quercetin and kaempferol had high affinity with FOS,TNF,TGFB1,HIF-1A and IL 1 A.Conclusion Guominjian can treat AD from multi-target and multi-pathway,which providing theoretical basis for further basic experimental research.关键词
过敏煎/特应性皮炎/网络药理学/炎症Key words
Guominjian/Atopic dermatitis/Network pharmacology/Inflammation分类
医药卫生引用本文复制引用
刘燕娇,李赵菊,蒋璐毅,王睿睿,张丽娟,张祎..基于网络药理学及分子对接技术探讨过敏煎对特应性皮炎的作用机制[J].现代医药卫生,2024,40(13):2166-2173,8.基金项目
国家自然科学基金项目(82160782) （82160782）
国家自然科学基金地区基金项目(81760741) （81760741）
云南省科技厅中医药基础研究联合专项重点项目(202301AZ070001-006) （202301AZ070001-006）
云南省科技厅中医药基础研究联合专项面上项目(202101AZ070001-187 （）
202301AZ070001-060). （）
