现代医药卫生2024，Vol.40Issue(13)：2206-2210,5.DOI:10.3969/j.issn.1009-5519.2024.13.010
妊娠晚期感染B族链球菌孕妇早产的危险因素及其pbp2x基因突变分析
Analysis of risk factors for preterm birth and pbp2x gene mutation in pregnant women infected with group B streptococcus in the third trimester of pregnancy
摘要
Abstract
Objective To analyze the risk factors for preterm birth in pregnant women with group B streptococcus(GBS)infection in a hospital and investigate the pbp2x gene mutation of GBS in pregnant women with preterm birth.Methods A total of 199 pregnant women with GBS infection who delivered in the hospital from January 2022 to May 2023 were selected and divided into the observation group and the control group according to whether they were preterm or not.Binary logistic regression model and receiver operating characteristic curve(ROC)were used to analyze the risk factors of preterm birth in pregnant women with GBS infection.First generation sequencing of pbp2x gene was performed on GBS samples from pregnant women with preterm birth.Results Among the 199 cases pregnant women with GBS infection,41(20.6％)had pre-term birth.Logistic regression analysis showed that age[odds ratio(OR)=1.151,P=0.004]and the number of abnormal items in oral glucose tolerance test(OGTT)(OR=2.995,P＜0.001)were independent risk fac-tors for preterm birth in pregnant women with GBS infection.The area under the curve(AUC)of the combi-nation of the two risk factors for preterm birth was 0.783,the best sensitivity was 75.6％,and the specificity was 69.0％,which was higher than that of single risk factor.Three missense mutations(1129G＞A,1148T＞G,1528A＞G)in pbp2x gene were found by Sanger sequencing.No mutation was found that could reduce the susceptibility of GBS to penicillin.Conclusion Age and the number of abnormal items in OGTT are risk fac-tors for preterm birth in pregnant women with GBS infection,and the combination of the two factors is better than each one alone in predicting preterm birth.No mutation of pbp2x gene affecting penicillin sensitivity has been found in GBS from pregnant women with preterm birth.关键词
B族链球菌/孕妇/早产/危险因素/pbp2x基因Key words
Group B streptococcus/Pregnant women/Preterm birth/Risk factors/pbp2x gene分类
医药卫生引用本文复制引用
文强,王秀,丁小莉,胡芷晴,徐志红..妊娠晚期感染B族链球菌孕妇早产的危险因素及其pbp2x基因突变分析[J].现代医药卫生,2024,40(13):2206-2210,5.基金项目
德阳市科技计划重点研发项目(2021SZZ070). （2021SZZ070）
