中国当代儿科杂志2024，Vol.26Issue(7)：695-700,6.DOI:10.7499/j.issn.1008-8830.2402073
儿童系统性红斑狼疮合并干燥综合征的临床特点及唇腺病理特征分析
Clinical characteristics and labial gland pathological features in children with systemic lupus erythematosus complicated by Sjögren's syndrome
程桑 1薛海燕 1曹兰芳1
作者信息
- 1. 上海交通大学医学院附属仁济医院儿科,上海 200001
- 折叠
摘要
Abstract
Objective To study the clinical manifestations,laboratory features,and labial gland pathological features in children with systemic lupus erythematosus(SLE)complicated by Sjögren's syndrome(SS).Methods A retrospective analysis was conducted on 102 children with SLE who underwent labial gland biopsies at Renji Hospital,Shanghai Jiao Tong University School of Medicine from January 2013 to December 2022.The children were divided into two groups based on the presence of SS:the SLE with SS group(SLE-SS;60 children)and the SLE-only group(42 children).According to the focus score(FS)of the labial glands,children in the SLE-SS group were further subdivided into FS≥4 subgroup(26 children)and FS<4 subgroup(34 children).The clinical data of the groups were compared.Results Compared to the SLE-only group,children in the SLE-SS group had less skin and mucosal involvement,were more likely to have positive anti-SSA and anti-SSB antibodies,and had higher levels of rheumatoid factor(P<0.05).There was no significant difference in treatment protocols between the two groups(P>0.05).Compared to the FS<4 subgroup,the FS≥4 subgroup had more frequent musculoskeletal involvement(P<0.05),but there was no significant difference in SLE disease activity or other major organ involvement between the subgroups(P>0.05).Conclusions Children with SLE complicated by SS are less likely to have skin and mucous membrane involvement and exhibit specific serological characteristics.The SLE-SS children with an FS≥4 are more likely to experience musculoskeletal involvement.However,FS is not associated with disease activity or other significant organ damage.关键词
干燥综合征/系统性红斑狼疮/临床特征/灶性指数/儿童Key words
Sjögren's syndrome/Systemic lupus erythematosus/Clinical characteristics/Focus score/Child引用本文复制引用
程桑,薛海燕,曹兰芳..儿童系统性红斑狼疮合并干燥综合征的临床特点及唇腺病理特征分析[J].中国当代儿科杂志,2024,26(7):695-700,6.
