中国当代儿科杂志2024，Vol.26Issue(7)：774-781,8.DOI:10.7499/j.issn.1008-8830.2312039
细胞焦亡在脓毒症心肌抑制中的作用研究进展
Recent research on pyroptosis in sepsis-induced myocardial depression
摘要
Abstract
Sepsis-induced myocardial depression(SIMD),a common complication of sepsis,is one of the main causes of death in patients with sepsis.The pathogenesis of SIMD is complicated,and the process of SIMD remains incompletely understood,with no single or definitive mechanism fully elucidated.Notably,pyroptosis,as a pro-inflammatory programmed cell death,is characterized by Gasdermin-mediated formation of pores on the cell membrane,cell swelling,and cell rupture accompanied by the release of large amounts of inflammatory factors and other cellular contents.Mechanistically,pyroptosis is mainly divided into the canonical pathway mediated by caspase-1 and the non-canonical pathway mediated by caspase-4/5/11.Pyroptosis has been confirmed to participate in various inflammation-associated diseases.In recent years,more and more studies have shown that pyroptosis is also involved in the occurrence and development of SIMD.This article reviews the molecular mechanisms of pyroptosis and its research progress in SIMD,aiming to provide novel strategies and targets for the treatment of SIMD.关键词
脓毒症/心肌抑制/细胞焦亡Key words
Sepsis/Myocardial depression/Pyroptosis引用本文复制引用
文日,张铁凝,杨妮,刘春峰..细胞焦亡在脓毒症心肌抑制中的作用研究进展[J].中国当代儿科杂志,2024,26(7):774-781,8.基金项目
国家自然科学基金项目(81971810 （）
82002021). （）
