中国临床医学2024，Vol.31Issue(3)：394-401,8.DOI:10.12025/j.issn.1008-6358.2024.20240366
白介素31在肺动脉高压患者血浆中的表达及其临床意义
Expression and clinical significance of interleukin-31 in plasma from patients with pulmonary arterial hypertension
摘要
Abstract
Objective To investigate the plasma level of interleukin-31(IL-31)in patients with pulmonary arterial hypertension(PAH)and its clinical relevance.Methods The patients who were diagnosed as PAH in Zhongshan Hospital,Fudan University from January 1,2021 to December 30,2023(PAH group)and the healthy people in the same period(control group)were selected.The clinical data and follow-up records were collected.Plasma levels of IL-31,IL-1β,IL-6,IL-10,IL-12p70,monocyte chemoattractant protein-1(MCP-1),tumor necrosis factor-α(TNF-α)and transforming growth factor-β1(TGF-β1)were detected by enzyme-linked immunosorbent assay(ELISA).Pearson correlation test was used to evaluate the correlations between IL-31 and right cardiac catheterization parameters,echocardiography parameters and blood indices in patients with PAH.Cox proportional hazard model was used to analyze the prognostic factors of patients in PAH group.Results A total of 50 patients with PAH and 22 healthy controls were included.There was no significant difference in age,gender,body mass index and left ventricular ejection fraction between the two groups.Compared with the control group,the plasma level of IL-31 in the PAH group was significantly higher(168.82[149.14,177.26]pg/mL vs 152.76[145.58,159.41]pg/mL,P=0.001).Pearson correlation test showed that the plasma level of IL-31 in PAH patient was positively correlated with mean pulmonary artery pressure(r=0.652,P＜0.001)and pulmonary vascular resistance(r=0.651,P＜0.001),but was negatively correlated with tricuspid annular plane systolic excursion(r=-0.496,P＜0.001).Cox proportional hazard model showed that higher plasma level of IL-31 was an independent predictor of readmission for heart failure/all-cause mortality in patients with PAH(HR=1.130,95％CI 1.052-1.214,P=0.001).Conclusions Plasma level of IL-31 may be significantly increased in patients with PAH and be positively correlated with the severity of PAH,and elevated level of IL-31 is predictive of poor prognosis in PAH patients.关键词
白介素31/肺动脉高压/临床相关性/预后Key words
interleukin-31/pulmonary arterial hypertension/clinical relevance/prognosis分类
医药卫生引用本文复制引用
詹智,张晓春,侯士强,管丽华,陈丹丹,潘文志,周达新..白介素31在肺动脉高压患者血浆中的表达及其临床意义[J].中国临床医学,2024,31(3):394-401,8.基金项目
上海市临床重点专科项目(shslczdzk01701).Supported by Shanghai Municipal Key Clinical Specialty Program(shslczdzk01701). （shslczdzk01701）
