中国临床医学2024，Vol.31Issue(3)：477-483,7.DOI:10.12025/j.issn.1008-6358.2024.20240447
支气管扩张症患者肺功能与临床特征的相关性
Associations of pulmonary function with clinical features in patients with bronchiectasis
摘要
Abstract
Objective To explore the relevant factors affecting pulmonary function in patients with bronchiectasis.Methods The patients diagnosed with bronchiectasis in Zhongshan Hospital,Fudan University from January 1,2017 to December 31,2019 were selected.Baseline data including demographic information,medical history,clinical manifestations,laboratory indicators,pulmonary function(spirometry and diffusing capacity),chest high-resolution computed tomography(HRCT),and treatment information.Patients were divided into different groups according to different grades of the percentage of predicted value of forced expiratory volume in one second(FEV1％pred)and the percentage of predicted value of diffusion capacity for carbon monoxide of lung(DLCO％pred),and the clinical characteristics,laboratory indicators were compared among the different groups.Logistic regression analysis was used to analyze the related factors affecting pulmonary function.Results 160 patients were included.There were statistically significant differences in the number of acute exacerbations past 1 year,number of involved lung lobes on CT images,Reiff score,clinical symptoms,positive proportion of Pseudomonas aeruginosa in sputum culture,24-hour sputum volume,and white blood cell count in patients with different FEV1％pred or DLCO％pred grades(P＜0.05).Multivariate logistic regression analysis showed that higher COPD assessment test(CAT score;OR=1.170,95％CI 1.059-1.293,P＜0.01),higher Reiff score(OR=1.541,95％CI 1.236-1.920,P＜0.01),Pseudomonas aeruginosa positive(OR=8.166,95％CI 1.727-38.623,P＜0.01)and disease duration≥ 10 years(OR=4.933,95％CI 1.371-17.753,P＜0.05)were independent risk factors of FEV1％pred＜50％;higher CAT score(OR=1.083,95％CI 1.003-1.169,P＜0.05)and the number of lobe involved on CT images ≥3(OR=3.914,95％CI 1.316-11.646,P＜0.05)were independent risk factors of DLCO％pred＜80％.Conclusion The longer disease duration,higher Reiff score,more lobes involved,the more severe the pulmonary function damage in bronchiectasis patients.关键词
支气管扩张症/肺功能/临床特征/Reiff评分Key words
bronchiectasis/lung function/clinical manifestation/Reiff score分类
医药卫生引用本文复制引用
周楚君,李华茵..支气管扩张症患者肺功能与临床特征的相关性[J].中国临床医学,2024,31(3):477-483,7.基金项目
上海市肺部炎症与损伤重点实验室(20DZ2261200),上海市临床重点专科建设项目(shslczdzk02201).Supported by Shanghai Key Laboratory of Lung Inflammation and Injury(20DZ2261200)and Shanghai Municipal Key Clinical Specialty(shslczdzk02201). （20DZ2261200）
