中国临床医学2024，Vol.31Issue(3)：484-490,7.DOI:10.12025/j.issn.1008-6358.2024.20240128
全身免疫炎症指数对急慢性胆囊炎的鉴别价值
Value of systemic immune-inflammation index distinguishing acute cholecystitis from chronic cholecystitis
摘要
Abstract
Objective To explore the value of systemic immune-inflammation index(SⅡ)in differentiating acute and chronic cholecystitis.Methods A total of 297 patients with cholecystitis who underwent cholecystectomy in Jinshan Hospital,Fudan University from August 2020 to November 2023 were selected,and were divided into acute cholecystitis group(n=192)and chronic cholecystitis group(n=105).The patients in acute cholecystitis group were further divided into severe subgroup(n=114)and mild subgroup(n=78).The differential diagnosis values of SⅡ and neutrophil-to-lymphocyte ratio(NLR)in acute and chronic cholecystitis were evaluated by ROC curve.Results Compared with chronic cholecystitis group,males were more,older,the incidence of hypertension was higher,drainage volume increased,drainage time,hospital time,and surgical duration were all longer,blood cells,neutrophil count,monocyte count increased,total bilirubin,direct bilirubin,and creatinine were higher,SⅡ and NLR increased in the acute cholecystitis group(P＜0.05).Compared with the severe subgroup,the drainage volume decreased,drainage time,hospital stay,and surgical duration were shorter,white blood cell count,neutrophil count,monocyte count,and total bilirubin decreased,while lymphocyte count increased,SⅡ and NLR decreased in the mild subgroup(P＜0.05).The optimal cutoff values of SⅡ and NLR for distinguishing acute cholecystitis from chronic cholecystitis were 797.96 and 3.65,and the AUC were 0.847 and 0.869,with 73.2％and 74.2％of sensitivity,and 86.7％and 89.5％of specificity.The optimal cutoff values of SⅡ and NLR for distinguishing acute severe cholecystitis from mild cholecystitis were 1 056.59 and 4.65,the AUC were 0.768 and 0.779,with 77.0％and 82.3％of sensitivity,and 67.5％and 62.3％of specificity.There was no statistically significant difference between the values of SⅡ and NLR for distinguishing acute severe and acute cholecystitis.Conclusion SⅡ is a good hematological indicator for distinguishing acute cholecystitis from chronic cholecystitis with similar value to NLR.关键词
急性胆囊炎/全身免疫炎症指数/中性粒细胞与淋巴细胞比值/预测Key words
acute cholecystitis/systemic immune-inflammation index/neutrophil-to-lymphocyte ratio/prediction分类
医药卫生引用本文复制引用
汤杰,赵文生,黄文海,黄安中..全身免疫炎症指数对急慢性胆囊炎的鉴别价值[J].中国临床医学,2024,31(3):484-490,7.基金项目
复旦大学附属金山医院青年课题(JYQN-JC-2021-01).Supported by Youth Project of Jinshan Hospital,Fudan University(JYQN-JC-2021-01). （JYQN-JC-2021-01）
