中国肿瘤外科杂志2024，Vol.16Issue(3)：253-260,8.DOI:10.3969/j.issn.1674-4136.2024.03.008
碘摄入量与甲状腺乳头状癌关系的Meta分析
Meta analysis of the relationship between iodine intake and papillary thyroid carcinoma
摘要
Abstract
Objective This study aimed to explore the correlation between iodine intake and papillary thyroid carcinoma(PTC).Methods After formulating a search strategy based on PICOS,12 case-control studies on iodine intake and PTC were collected from PubMed,Cochrane Library,Web of Science,CNKI,and Wanfang databases,including a total of 6 214 research subjects,and Meta-analysis was performed.Results The Meta-analysis indicated that there was a positive correlation between excessive iodine intake and the incidence of PTC(OR=5.66,95％CI:2.25～12.68,P＜0.05),while moderate iodine intake could reduce the risk of PTC(OR=0.26,95％CI:0.13～0.52,P＜0.01).Excessive iodine intake may not be related to such factors as extrathyroidal extension(ENE),the central lymph node metastasis(CLNM),and BRAF gene mutations.Conclusions Excessive iodine intake increases the risk of PTC,and moderate iodine intake may be a protective factor for PTC.关键词
甲状腺乳头状癌/碘/碘摄入量/碘营养/尿碘/Meta分析Key words
Papillary thyroid carcinoma/Iodine/Iodine intake/Iodine nutrition/Urinary iodine/Meta-analysis引用本文复制引用
尉志伟,徐斐,王廷..碘摄入量与甲状腺乳头状癌关系的Meta分析[J].中国肿瘤外科杂志,2024,16(3):253-260,8.基金项目
陕西省卫生健康科研基金扶植项目(2018D070) （2018D070）
