中国肿瘤外科杂志2024，Vol.16Issue(3)：288-295,8.DOI:10.3969/j.issn.1674-4136.2024.03.014
结直肠癌肿瘤微环境中CD8+T细胞研究进展
Research advancements in the tumor microenvironment of colorectal cancer with regards to CD8+T cells
摘要
Abstract
The incidence of colorectal cancer(CRC)is steadily increasing worldwide and has now emerged as the most prevalent gastrointestinal malignancy globally.CD8+T cells play a pivotal role in tumor immunity against CRC and serve as the primary target for immunotherapy,thereby exerting a significant impact on treatment outcomes and patient prognosis.However,due to the inhibitory effects imposed by various cellular components,cytokines,and metabolites within the tumor microenvironment,CD8+T cells often experience functional inactivation.Therefore,comprehending the intricate interactions between CD8+T cells and the colorectal tumor microenvironment is imperative for devising more efficacious therapeutic strategies.This review paper provides an overview of recent advancements in this field.关键词
CD8+T细胞/CRC/肿瘤微环境Key words
CD8+T cell/Colorectal cancer/Tumor microenvironment引用本文复制引用
刘天宇,陆晨,鄂一民,喻春钊..结直肠癌肿瘤微环境中CD8+T细胞研究进展[J].中国肿瘤外科杂志,2024,16(3):288-295,8.基金项目
国家自然科学基金面上项目(82373293) （82373293）
江苏省"333工程"培养资金(BRA2020091) （BRA2020091）
江苏省卫生健康委科研项目(ZD2022063) （ZD2022063）
