中国肿瘤外科杂志2024，Vol.16Issue(3)：302-307,6.DOI:10.3969/j.issn.1674-4136.2024.03.016
癌症成纤维细胞成为靶点在三阴性乳腺癌免疫治疗中的应用前景
Application prospect of cancer fibroblasts as targets in triple negative breast cancer immunotherapy
摘要
Abstract
It is believed that tumor microenvironment contribute greatly to the progression of a series of cancers,including breast cancer.Cancer associated fibroblasts(CAFs)are the most abundant components of tumor microenvironment.Research has shown that CAFs in cancer originate from various types of cells,promoting the production and progression of malignant tumors by secreting factors,producing exosomes,releasing nutrients,reshaping the extracellular matrix,and inhibiting immune cell function.Due to their specific distribution in tumors and unique biomarkers,CAFs have the potential to become therapeutic targets for cancer.Currently,drugs that block the action of CAFs on surrounding cells have been developed and applied in clinical trials.Further understanding of the mechanisms involved in the tumor promoting and anti-tumor effects of CAFs can provide the possibility of unmapped therapeutic interventions aimed at controlling some matrix properties,further manipulate CAFs and use their biological characteristics to restore the dysfunctional microenvironment and prevent the progress of breast cancer.关键词
乳腺癌/免疫治疗/肿瘤微环境/肿瘤成纤维细胞/综述Key words
Breast cancer/Immunotherapy/Tumor Microenvironment/Tumor Fibroblasts/Review引用本文复制引用
朱瑜,张建,侯俊宸,徐迪,王丹丹..癌症成纤维细胞成为靶点在三阴性乳腺癌免疫治疗中的应用前景[J].中国肿瘤外科杂志,2024,16(3):302-307,6.基金项目
国家自然科学基金青年基金(82303449) （82303449）
