中国肿瘤外科杂志2024，Vol.16Issue(3)：308-313,6.DOI:10.3969/j.issn.1674-4136.2024.03.017
甲状腺癌相关基因检测的研究进展
Research progress in thyroid cancer related gene detection
安文超 1于文斌2
作者信息
- 1. 010000 内蒙古呼和浩特,内蒙古医科大学 研究生院||010000 内蒙古呼和浩特,北京大学肿瘤医院内蒙古医院 头颈外科
- 2. 010000 内蒙古呼和浩特,北京大学肿瘤医院内蒙古医院 头颈外科
- 折叠
摘要
Abstract
Thyroid cancer is the most common malignant tumour in head and neck surgery,as well as one of the most common endocrine malignancies.The effectiveness of surgical treatment for some types of thyroid cancer is not yet significant,and the sensitivity of radiotherapy and chemotherapy is also low.In order to find better treatment options,recent researches have shown that mutations and rearrangements of v-raf murine sarcoma viral oncogene homolog B1(BARF),REarranged during Transfection(RET/PTC),telomerase reverse tran-scriptase(TERT),tumor protein 53(P53),mouse sarcoma virus(RAS)and other genes are the main factors leading to the occurrence and development of thyroid cancer.Related genetic testing can be used to predict the malignancy and prognosis of thyroid cancer,and can help identify treatment targets for further use of targeted drugs to treat this portion of refractory thyroid cancer.Familiarity with the genetic mutations in thyroid cancer patients is important for clarifying its pathogenesis and developing individualised treatment plans.This article provides an overview of the relationship between the relevant genes and cancer development as well as the research progress of the genes,aiming to provide a reference for the clinical diagnosis and treatment of thyroid cancer.关键词
甲状腺癌/鼠类肉瘤滤过性毒菌致癌同源体B1/转染重排/端粒酶反转录酶/P53/鼠肉瘤病毒Key words
Thyroid cancer/BRAF/RET/PTC/TERT/P53/RAS引用本文复制引用
安文超,于文斌..甲状腺癌相关基因检测的研究进展[J].中国肿瘤外科杂志,2024,16(3):308-313,6.
