中华临床免疫和变态反应杂志2024，Vol.18Issue(3)：215-220,6.DOI:10.3969/j.issn.1673-8705.2024.03.002
骨骼肌单器官血管炎临床、影像及病理分析
Clinico-imageologico-pathologic analysis of single-organ skeletal muscle vasculitis
摘要
Abstract
Objective To delineate clinico-imageologico-pathologic features of single-organ skeletal muscle vasculitis(SoSMV).Methods We retrospectively analyzed SoSMV cases observed over a 6-year peri-od from our center.Results We included 13 patients(6 women and 7 men)with a median age of 49 years.The main clinical manifestations were lower limb myalgia(100％),muscle swelling(76.9％)and fever(53.8％).The most frequent laboratory findings include high ESR(100.0％),high CRP(100.0％)and leukocytosis(53.8％).There was no hyper-CK-emia founded.Nine patients underwent EMG examination and 1 showed myogenic injury.On MRI,diffuse,patchy,or ramified hyperintense signals in T2WI and/or STIR and normal/hypointense in T1WI of one or several leg muscles was founded in all 13 patients.All muscle speci-mens showed nongranulomatous vasculitis affecting small sized artery.Corticosteroids(100.0％)and immuno-suppressants(46.2％)were the main agents prescribed.With a median follow-up of 36 months,sustained re-mission was observed in 7 patients(53.8％),relapses occurred in 6 patients(46.2％).Conclusion SoSMV should be considered for patients with lower limb myalgia,high inflammatory markers and normal/low CK lev-el.Lower extremity MRI has a higher ability to detect vasculitic muscle disease and could constitute a useful complementary examination for SoSMV.Corticosteroid and immunosuppressant are effective.关键词
骨骼肌血管炎/单器官血管炎Key words
skeletal muscle vasculitis/single-organ vasculitis引用本文复制引用
李嗣钊,卢昕..骨骼肌单器官血管炎临床、影像及病理分析[J].中华临床免疫和变态反应杂志,2024,18(3):215-220,6.基金项目
中央高水平医院临床研究专项(2022-NHLHCRF-YS-02) National Hogh Level Hospital Clinical Research Funding(2022-NHLHCRF-YS-02) （2022-NHLHCRF-YS-02）
