中华临床免疫和变态反应杂志2024，Vol.18Issue(3)：245-250,6.DOI:10.3969/j.issn.1673-8705.2024.03.006
系统性红斑狼疮合并COVID-19住院患者的临床特征分析
Analysis of characteristics in patients with systemic lupus erythematosus and COVID-19 admitted to the hospital
摘要
Abstract
Objective To explore the characteristic analysis of hospitalized patients with Systemic Lu-pus Erythematosus(SLE)infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Methods Patients with SLE and COVID-19 who visited the First Affiliated Hospital of Nanchang University from December 2022 to February 2023 were included.All patients were divided into two groups based on whether they received hospital treatment:non-hospitalized and hospitalized.Demographic data,clinical symp-toms,and laboratory tests were compared between the two groups.The ability of lymphocytes/monocytes(LMR),neutrophils/lymphocytes(NLR),platelets/lymphocytes(PLR),systemic immune inflammatory in-dex(S Ⅱ),S Ⅱ/albumin,ESR/lymphocytes(ELR)and C-reactive protein/lymphocytes(CLR)to predict the hospitalization of SLE patients with COVID-19 was determined.Results There were statistically significant differences between the two groups in terms of age,glucocorticoid dosage,SLEDAI score,erythrocyte sedi-mentation rate,C-reactive protein,platelets,lymphocytes,albumin,NLR,PLR,LMR,CLR,ELR,S Ⅱ,and S Ⅱ/ALB(P＜0.05).Multivariate logistic regression analysis showed that CLR(OR=1.16),glucocorticoid dosage(OR=1.11),and SLEDAI score(OR=1.23)were the clinical characteristics associ-ated with hospitalization in SLE patients with COVID-19.ROC curve analysis showed that the area under curve of CLR was 0.751,with a sensitivity of 50.0％and specificity of 94.0％;the AUC for glucocorticoid dosage was 0.778,with a sensitivity of 76.9％and specificity of 75.9％;and the AUC for SLEDAI was 0.754,with a sensitivity of 50.0％and specificity of 91.6％.Conclusions Higher CLR,glucocorticoid dosage,and SLEDAI score are the clinical characteristics associated with hospitalization in SLE patients with COVID-19.关键词
系统性红斑狼疮/COVID-19/住院患者/临床特点Key words
systemic lupus erythematosus/COVID-19/hospitalization/clinical characteristics引用本文复制引用
刘鹏程,张敏,李建斌,余淑娇,吴锐..系统性红斑狼疮合并COVID-19住院患者的临床特征分析[J].中华临床免疫和变态反应杂志,2024,18(3):245-250,6.基金项目
国家自然科学基金(82260898) National Natural Science Foundation of China(82260898) （82260898）
