中国现代医生2024，Vol.62Issue(18)：8-12,5.DOI:10.3969/j.issn.1673-9701.2024.18.002
脓毒症患者并发抗生素相关性腹泻的危险因素分析
Analysis of risk factors for antibiot-associated diarrhea in sepsis patients
摘要
Abstract
Objective To explore the incidence and risk factors of antibiot-associated diarrhea(AAD)in patients with sepsis.Methods A total of 126 patients with sepsis admitted to Department of Critical Care Medicine,Jinhua Hospital Affiliated to Zhejiang University School of Medicine from July 2021 to July 2023 were selected as the subjects.They were divided into AAD group and non AAD group based on whether AAD occurred.Compare the clinical data and antibiotic use between two groups of patients,and use Logistic regression analysis to identify the risk factors for AAD in sepsis patients.Results There were 72 cases of respiratory system infections,18 cases of urinary system infections,15 cases of bloodstream infections,12 cases of chest and abdominal infections,and 9 cases of other infections in 126 patients with sepsis;32 cases(25.4%)developed AAD.Logistic multiple regression analysis showed that age≥60 years,lactic acid(Lac)level,albumin(ALB)level,use of carbapenems and enzyme inhibitors,combination of antibiotics,using hormones,and length of hospital stay were risk factors for AAD in sepsis patients(95%CI were 0.847-0.983,0.074-0.527,1.147-2.034,0.624-1.687,2.132-5.220,0.439-0.882,0.411-0.853,0.478-0.848,P<0.05).Conclusion Sepsis patients of department of critical care medicine have a high risk of developing AAD.Age≥60 years old,Lac level,ALB level,use of carbapenems and enzyme inhibitors,combination of antibiotics therapy,using hormones,and length of hospital stay are risk factors for AAD in sepsis patients.关键词
脓毒症/重症医学科/抗生素相关性腹泻/危险因素Key words
Sepsis/Department of critical care medicine/Antibiot-associated diarrhea/Risk factors分类
医药卫生引用本文复制引用
郑卫涛,王生超,邵兴,童洪杰,陈琨..脓毒症患者并发抗生素相关性腹泻的危险因素分析[J].中国现代医生,2024,62(18):8-12,5.基金项目
浙江省金华市中医药科学技术研究计划项目(2023KY01) （2023KY01）
