早孕期子宫动脉血流动力学参数、血清Hcy及D-二聚体在复发性流产中的检测价值OA

Objective To study the value of hemodynamics parameters,homocysteine(Hcy)and D-dimer levels in uterine artery during early pregnancy in patients with recurrent spontaneous abortion(RSA).Methods A total of 72 patients with RSA in Xuancheng People's Hospital from November 2020 to November 2022 were enrolled,and another 50 healthy women with normal results on prenatal ultrasonography were set as control group.Both groups underwent color Doppler ultrasonography and serum detection during early pregnancy,then parameters including pulsatile index(PI),ratio of peak flow velocity during systole to diastole(S/D),resistance index(RI),Hcy and D-dimer were compared between two groups.Logistic regression model was used to analyze the influencing factors of RSA occurrence,and receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of each index to RSA.Results The values of PI,S/D,RI,Hcy and D-dimer in RSA group were higher than those in control group(P<0.05).The values of PI,S/D,RI,Hcy and D-dimer increased as risk factors for RSA(P<0.05).ROC curve denoted that the area under the curve(AUC)of PI,S/D,RI,Hcy and D-dimer dimerin the diagnosis of RSA were 0.778,0.826,0.819,0.778 and 0.756,respectively,and the AUC of combined detection of the above five parameters was 0.858,with a sensitivity of 75.0%and a specificity of 80.0%,indicating that the diagnostic value of joint detection was better than that of single detection.Conclusion The ascending uterine artery hemodynamic parameters,elevated Hcy and D-dimer level during early pregnancy are the risk factors for RSA patients,and the combined detection of all indicators has certain predictive value for RSA diagnosis.