摘要
Abstract
Objective To study the clinical value of miR-181a and galectin-3(GAL3)in the assessment of the condition and prognosis of acute ischemic stroke(AIS).Methods A total of 82 AIS patients(AIS group)diagnosed and treated from January 2019 to January 2021 and patients with cerebrovascular disease without ischemic stroke during the same period(control group)were selected as the research subjects,and the serum miR-181a,GAL3,National Institute of Health stroke scale(NIHSS),modified Barthel index(MBI)and Fugl-Meyer assessment of gait(FMA)of the two groups were compared.Pearson correlation analysis was performed on the correlation between miR-181a,GAL3 and neurological function indicators(NIHSS,MBI,FMA score).Receiver operating characteristic curve(ROC)was used to analyze the effectiveness of miR-181a and GAL3 in predicting poor 1-year prognosis in AIS patients.Logistic regression analysis of risk factors for 1-year death in postmenstrual AIS patients.Results Compared with control group,the miR-181a,GAL3,and NIHSS scores of patients in AIS group were significantly higher(P<0.05),and the MBI score and FMA score were significantly lower(P<0.05).In AIS group,patients'miR-181a and GAL3 were positively correlated with the NIHSS score(r>0,P<0.05),and were negatively correlated with the MBI score and FMA score(r<0,P<0.05).The sensitivity,specificity,and area under the curve(AUC)of miR-181a and GAL3 in predicting poor 1-year prognosis of AIS patients in the AIS group are higher than the NIHSS score,MBI score,and FMA score;The sensitivity of miR-181a combined with GAL3 in predicting poor 1-year prognosis in patients in AIS group,specificity,and AUC were all higher than miR-181a,GAL3,NIHSS score,MBI score,and FMA score.miR-181a≥1.3,GAL3≥12.3ng/ml,NIHSS score≥17.4 points,MBI score<67.6 points,and FMA score<84.2 points were independent risk factors for 1-year death in AIS patients(P<0.05).Conclusion The serum levels of miR-181a and GAL3 in AIS patients are significantly increased,which have certain clinical value in the evaluation of the condition and prognosis of AIS.关键词
急性缺血性脑卒中/miR-181a/半乳凝素-3/病情/预后/临床价值Key words
Acute ischemic stroke/miR-181a/GAL3/Condition/Prognosis/Clinical value分类
医药卫生
