基于Kisspeptin/GPR54系统探讨新加二甲地黄汤对PCOS模型大鼠卵泡发育的影响OA
Exploring the effect of Xinjia Erjia Dihuang Tang on follicular development in PCOS model rats based on the Kisspeptin/GPR54 system
目的 探讨经新加二甲地黄汤干预后的多囊卵巢综合征(polycystic ovary syndrome,PCOS)模型大鼠的卵泡发育情况及其可能存在的效应机制.方法 筛选 28 只拥有规律动情周期的雌性SD大鼠,随机分为正常对照组、模型组、中药组及西药组,每组 7 只.除正常对照组外,其余三组均连续予来曲唑-羧甲基纤维素混悬液 0.1mg/(kg·d)灌胃,以构建PCOS大鼠模型.自第 22 天起,中药组以新加二甲地黄汤 5.268g/(kg·d)…查看全部>>
Objective To investigate the development of follicles in polycystic ovary syndrome(PCOS)model rats treated with Xinjia Erjia Dihuang Tang and its possible mechanism.Methods Twenty-eight female SD rats with regular estrous cycle were selected and randomly divided into normal control group,model group,Chinese medicine group and Western medicine group,with 7 rats in each group.In addition to the normal control group,the other three groups were continuously give…查看全部>>
石明晴;王津;徐小雨;蓝关翠
丽水市中医院妇产科,浙江丽水 323000丽水市中医院妇产科,浙江丽水 323000浙江中医药大学第三临床医学院,浙江杭州 310053丽水市中医院妇产科,浙江丽水 323000
临床医学
新加二甲地黄汤多囊卵巢综合征G蛋白偶联受体54Kisspeptin性激素
Xinjia Erjia Dihuang TangPolycystic ovary syndromeG-protein-coupled receptor 54KisspeptinSex hormones
《中国现代医生》 2024 (18)
90-95,6
浙江省中医药科学研究基金项目(2021ZB338)浙江省卫生健康科技计划项目(2021RC147)
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