顺铂致急性肾损伤肾脏糖酵解和氨基酸代谢改变的研究OA北大核心CSTPCD
Changes in renal cell glycolysis and amino acid metabolism during cisplatin-induced acute kidney injury
目的 评估顺铂急性肾损伤过程中肾细胞能量代谢变化.方法 成年CD-1雄性小鼠经腹腔注射给予单剂量顺铂(20 mg/kg),检测肾功能和肾组织病理学;转录组分析顺铂对人肾小管上皮细胞基因表达的调控作用并富集通路;LC-MS/MS检测肾脏糖酵解和氨基酸代谢物含量.结果 处理组小鼠血清尿素氮和肌酐水平明显上升;病理组织学观察到肾小管上皮细胞发生肿胀和脱落;转录组分析显示顺铂处理72 h引起HK-2细胞2632个基因上调和2799个基因下调;GO和KEG…查看全部>>
Objective To evaluate the change of energy metabolism during cisplatin-induced acute kidney injury.Methods Adult CD-1 male mice were intraperitoneally injected with a single dose of cisplatin (20 mg/kg), and renal function and renal tissue pathology were tested;gene expression was analyzed and signaling pathways were en-riched in cisplatin-treated renal tubular epithelial cells using transcriptome; the contents of renal glycolysis and a-mino acid metabolites…查看全部>>
徐申;梁楠楠;任亚辉;何奕樟;张涛;于德新
安徽医科大学第二附属医院泌尿外科,合肥 230601安徽医科大学公共卫生学院,合肥 230032安徽医科大学第二附属医院泌尿外科,合肥 230601安徽医科大学第二附属医院泌尿外科,合肥 230601安徽医科大学第二附属医院泌尿外科,合肥 230601安徽医科大学第二附属医院泌尿外科,合肥 230601
临床医学
顺铂急性肾损伤细胞代谢糖酵解氨基酸代谢
cisplatinacute kidney injurycellular metabolismglycolysisamino acid metabolism
《安徽医科大学学报》 2024 (5)
747-752,760,7
国家自然科学基金(编号:82204493)安徽省自然科学基金(编号:2208085QH237)
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