抗核抗体阳性及干预治疗与反复种植失败辅助生殖结局相关性研究OA北大核心CSTPCD

Objective To investigate the impact of positive antinuclear antibody(ANA)and subsequent interven-tion therapy on the assisted reproductive technology outcomes among the patients experiencing recurrent implanta-tion failure(RIF).Methods A retrospective study was conducted on 344 RIF patients.Based on ANA test re-sults,the patients were divided into ANA-positive group(294 cases)and negative control group(50 cases).The ANA-positive group was further divided into a low titer group(214 cases)and a high titer group(80 cases).Com-parative statistical analyses such as the Wilcoxon rank-sum test,Mann-Whitney U test,Kruskal-Wallis test and chi-square test,etc.were employed to evaluate differences in general clinical data,embryo-related parameters,and pregnancy outcomes between the positive and negative groups.The impact of ANA on the assisted reproductive out-comes of patients with recurrent implantation failure was analyzed,and the outcomes of ANA-positive patients after intervention therapy were also analyzed.Results Notably,the clinical pregnancy rates of patients in the ANA-pos-itive low titer group and high titer group were significantly lower than those in the negative control group(P＜0.001).Similarly,the rates of fertilization and cleavage of oocytes in ANA-positive patients were also significantly lower than those in the negative control group(P＜0.05).For patients who did not achieve pregnancy after embryo transfer due to ANA positivity,immunomodulatory therapy significantly improved both the clinical pregnancy rate and cumulative clinical pregnancy rate(P＜0.05).Conclusion Compared with the negative control group,the clinical pregnancy rates decrease in both ANA-positive low titer subgroup and high titer subgroup.However,clini-cal intervention therapy enhances the single-cycle clinical pregnancy and cumulative pregnancy rates among ANA-positive patients,indicating that ANA positivity is an important factor in RIF.Immunomodulatory therapy is an ef-fective measure to improve recurrent implantation failure among ANA-positive patients.