安徽医科大学学报2024，Vol.59Issue(6)：1081-1088,8.DOI:10.19405/j.cnki.issn1000-1492.2024.06.026
亚甲基四氢叶酸还原酶基因多态性与阿尔茨海默病的相关性临床研究
The clinical correlations of gene polymorphism of methylenetetrahydrofolate reductase with Alzheimer's disease
摘要
Abstract
Objective To investigate the correlation between the methylenetetrahydrofolate reductase(MTHFR)C677T polymorphism and disease in the course of Alzheimer's disease(AD),as well as whether whether it is af-fected by APOE gene.Methods A total of 74 AD patients,85 aMCI patients and 81 healthy controls(HC)were included.The levels of serum homocysteine(Hcy),folate,and vitamin B12,as well as the genotypes of MTHFR C677T and APOE,were determined.Logistic regression analysis was conducted to explore the relationship between MTHFR C677T polymorphism and the risk of AD and aMCI,as well as in different APOE ε4 subgroups.Results Compared with HC group,the serum Hcy levels in AD group and aMCI group were significantly higher(P＜0.001,P＜0.001),while serum folate levels in aMCI group was significantly lower(P=0.017).The serum fo-late level was significantly lower(P=0.038)in individuals with the MTHFR TT genotype compared to those with CC and CT genotypes,while the serum Hcy level was significantly higher(P=0.002).Regression analysis showed that the MTHFR TT genotype might increase the risk of aMCI in the subgroup of APOE e4 non-carriers(OR=3.670,95％CI=1.077-12.509,P=0.038),but not in APOE e4 carriers.Conclusion MTHFR C677T polymorphism plays an important role in Hcy metabolism,which leads to increased serum Hcy levels and decreased folate levels.In APOE ε4 non-carriers,the MTHFR TT genotype may increase the risk of aMCI.关键词
阿尔茨海默病/遗忘型轻度认知障碍/亚甲基四氢叶酸还原酶/同型半胱氨酸Key words
Alzheimer's disease/amnestic mild cognitive impairment/methylenetetrahydrofolate reductase/ho-mocysteine分类
医药卫生引用本文复制引用
游孟哲,周霞,尹文文,万珂,孙中武..亚甲基四氢叶酸还原酶基因多态性与阿尔茨海默病的相关性临床研究[J].安徽医科大学学报,2024,59(6):1081-1088,8.基金项目
安徽省重点研究与开发计划项目(编号:202104j07020031) （编号:202104j07020031）
