安徽医科大学学报2024，Vol.59Issue(7)：1123-1128,6.DOI:10.19405/j.cnki.issn1000-1492.2024.07.003
肾素-血管紧张素系统在血管性痴呆大鼠心肌损伤中的作用
Role of the renin-angiotensin system in myocardial injury in rats with vascular dementia
摘要
Abstract
Objective To observe the role of the renin-angiotensin system in myocardial injury induced by experi-mental vascular dementia.Methods Eighteen adult male rats were categorized into a normal group,sham group,and modified 2-vessel occlusion group(model).To assess the myocardial injury caused by experimental vascular dementia,immunostaining was conducted to evaluate the interstitial collagen fraction and myocyte cross-sectional ar-ea.The concentrations of angiotensin Ⅱ(Ang Ⅱ)and angiotensin 1-7(Ang1-7)in the serum,as well as the ex-pression levels of angiotensin converting enzyme(ACE),angiotensin converting enzyme 2(ACE2),Ang Ⅱ,Ang1-7,angiotensin type 1(AT1)receptor,and Mas receptor in the myocardium,were assessed.Results Modified 2-vessel occlusion led to pronounced cognitive dysfunction(P＜0.01)and myocardial injury(P＜0.000 1)when compared to the sham and normal groups.Additionally,modified 2-vessel occlusion induced significant upregulation of the ACE/Ang Ⅱ/AT1 receptor axis(P＜0.01)and downregulation of the ACE2/Ang1-7/Mas axis(P＜0.05)of the renin-angiotensin system in the myocardium.Conclusion Myocardial injury in rats with experimental vascu-lar dementia may be related to dysregulation of the renin-angiotensin system.关键词
血管性痴呆/肾素-血管紧张素系统/心肌损伤/脑-心相互作用Key words
vascular dementia/renin-angiotensin system/myocardial injury/brain-heart interaction分类
医药卫生引用本文复制引用
李键,朱博涵,高鹏,陈极,陈和木,高晓平..肾素-血管紧张素系统在血管性痴呆大鼠心肌损伤中的作用[J].安徽医科大学学报,2024,59(7):1123-1128,6.基金项目
安徽省高等学校科学研究项目(编号:2022AH051160) （编号:2022AH051160）
