安徽医科大学学报2024，Vol.59Issue(7)：1269-1274,6.DOI:10.19405/j.cnki.issn1000-1492.2024.07.025
尿酸/高密度脂蛋白胆固醇比值与房颤射频消融术后复发的相关性
Correlation of uric acid to HDL-C ratio with recurrence after radiofrequency ablation of atrial fibrillation
摘要
Abstract
Objective To investigate the correlation between uric acid to high-density lipoprotein cholesterol ratio(UHR)and late recurrence after radiofrequency ablation in patients with non-valvular atrial fibrillation(AF).Methods The clinical data of 586 patients with non-valvular AF underwent catheter radiofrequency ablation for the first time from January 2018 to January 2022 were selected,and the study population was classified into a low-value group(n=196),a medium-value group(n=195),and a high-value group(n=195)according to the trichoto-mous method based on the UHR value,with late recurrence of AF as the endpoint event of the follow up.The gener-al data and laboratory indexes were compared among the three groups.Survival curves were estimated and plotted u-sing the Kaplan-Meier method.Multivariate COX regression analysis was used to evaluate the independent correla-tion between UHR and recurrence of AF after ablation,followed by subgroup analysis.Results Late recurrence of AF was documented in a total of 182(31.1％)patients during the follow-up time.The Kaplan-Meier survival curve showed a gradual decrease in the maintenance rate of sinus rhythm across the UHR low-value group,middle-value group,and high-value group(Log-rank test,P＜0.001).In the fully-adjusted model,compared with the patients in the low-value group,the medium-value and high-value groups had a post-ablation late recurrence of AF with HR(95％CI,P)were 1.56(0.99-2.42,P=0.057)and 2.03(1.28-3.23,P=0.003),respectively.Subgroup a-nalysis showed that the association between UHR and late recurrence of AF after ablation was remarkable among pa-tients with aged≥60 years,BMI≥25 kg/m2,persistent AF,LAD≥4.3 cm,hypertension,without heart failure and without hyperlipidemia.Conclusion Higher UHR values in patients with non-valvular AF are independently asso-ciated with an increased risk of late recurrence of AF after radiofrequency ablation procedures.关键词
尿酸/高密度脂蛋白胆固醇/心房颤动/射频消融术/晚期复发Key words
uric acid/high-density lipoprotein cholesterol/atrial fibrillation/radiofrequency ablation/late recur-rence分类
医药卫生引用本文复制引用
王保龙,王昌会..尿酸/高密度脂蛋白胆固醇比值与房颤射频消融术后复发的相关性[J].安徽医科大学学报,2024,59(7):1269-1274,6.基金项目
国家自然科学基金区域联合基金重点项目(编号:U22A20154) （编号:U22A20154）
安徽省高等学校自然科学研究项目(编号:2023AH053295) （编号:2023AH053295）
