不同产地宽筋藤药材质量研究OA
The Quality of Caulis Tinosporae Sinensis from Different Origins
目的:建立宽筋藤药材UPLC特征图谱及含量测定方法,对不同产地宽筋藤药材进行综合评价.方法:对21批不同产地宽筋藤药材进行特征图谱及含量同法测定,并结合聚类分析、偏最小二乘法分析对其质量进行评价.结果:所建立的特征图谱共确定了 20个共有峰,并通过对照品比对指认了其中2个成分,分别为紫丁香苷和木兰花碱,聚类及偏最小二乘法分析显示21批样品可以分为两类,含量测定结果则显示不同产地之间的样品含量差异较大.结论:所建立的方法科学合理,能更全面反映不同产地宽筋藤药材的质量,为宽筋藤药材的质量控制提供了参考.
Objective:To establish the UPLC characteristic chromatogram and content determination method of Caulis Tinosporae Sinensis for its comprehensive evaluation from different origins.Methods:The characteristic chromatogram method,the same as content determination method,was used to determine the 21 batches of Caulis Tinosporae Sinensis from different origins,combined with cluster analysis and partial least-squares regres-sion analysis,to evaluate the quality.Results:The total of 20 common peaks were determined by the established characteristic chromatogram method and 2 of those peaks were identified by standards which were syringin and magnoflorine.The cluster analysis and partial least-squares regression analysis results showed that the 21 batches were classified into two categories.And the content determination results display the difference among the origins.Conclusion:The established method is scientifically reasonable which can fully reflect the quality of different origins of Caulis Tinosporae Sinensis that can provide a reference for the quality control of Caulis Tinosporae Sinensis.
许广宁;曹斯琼;何嘉莹;邱韵静;胡绮萍;潘礼业;孙冬梅
广东省药品监督管理局审评认证中心,广东广州 510000广东一方制药有限公司·广东省中药配方颗粒企业重点实验室,广东佛山 528244
中医学
宽筋藤特征图谱含量测定产地质量控制
Caulis Tinosporae Sinensischaracteristic chromatogramcontent determinationoriginquality control
《中医康复》 2024 (002)
14-18 / 5
国家工信部2022年产业技术基础公共服务平台项目——中药全产业链质量技术服务平台,编号:2022-230-221
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