方药联合温针灸治疗脾肾气虚兼血瘀型糖尿病肾病的疗效及对肾脏纤维化指标的影响OA

Objective:To observe and recognize the clinical efficacy of formulae combined with warm acupuncture in the treatment of diabetic ne-phropathy patients with spleen-kidney qi deficiency cum blood stasis and the effect on renal fibrosis indexes.Method:Sixty-four patients with dia-betic nephropathy with blood stasis and spleen-kidney qi deficiency were selected and divided into 32 cases in the control group and 32 cases in the treatment group by the random number table method.The control group was treated with western medicine and oral Irbesartan;the treatment group was treated with Chinese herbal soup formula combined with warm acupuncture on the basis of the control group to strengthen the spleen and kidney and activate blood.Both groups were treated with 4 weeks as a course of treatment for 2 consecutive courses.The blood creatinine(SCr),urea nitro-gen(BUN),24-hour urine protein quantification,total cholesterol(TC),triacylglycerol(TG),fasting blood glucose(FBG),glycosylated hemoglobin(HbAlc),cystatin C(CysC),metalloproteinase inhibitor-1(TIMP-1),transforming growth factor-β1(TGF-β1),and type Ⅳ hemoglobin were com-pared between the two groups after two courses of treatment.-β1),and collagen type Ⅳ(CⅣ).Results:SCr,BUN,24-hour urine protein quantifica-tion,TC,TG,FBG,HbA1c,CysC,TIMP-1,TGF-β1,and C Ⅳ levels were reduced in both groups(P＜0.05),and the indexes in the treatment group were lower than those in the control group(P＜0.05).The total effective rate of Chinese medicine evidence efficacy evaluation in the treatment group was significantly higher than that in the control group(P＜0.05).Conclusion:The self-developed formula of strengthening the spleen,benefiting the kidney and invigorating the blood,combined with warm acupuncture treatment can reduce kidney damage in diabetic nephropathy,reduce urinary protein and delay the progression of kidney fibrosis,thus improving the quality of survival of patients.