北京师范大学学报（自然科学版）2024，Vol.60Issue(3)：305-309,5.DOI:10.12202/j.0476-0301.2023256
遗传关联分析中的一个稳健检验
A robust test for genetic association analysis
摘要
Abstract
To test association of a biallelic single nucleotide polymorphism(SNP)with corresponding disease,a new test statistic based on exponential function summation of absolute values of trend tests(SEA)is constructed.Simulation indicates that SEA could control Type I error well and has good performance in all the genetic models.The proposed test statistic is applied to 17 SNPs associated with complex diseases,these SNP are found strongly associated with corresponding diseases.关键词
全基因组关联研究/Cochran-Armitage趋势检验/稳健检验/外显率/次基因频率Key words
genome-wide association study/Cochran-Armitage trend test/robust test/penetrance/minor allele frequency分类
数学引用本文复制引用
蔡定教,童行伟..遗传关联分析中的一个稳健检验[J].北京师范大学学报（自然科学版）,2024,60(3):305-309,5.基金项目
国家自然科学基金资助项目(12171374) （12171374）
教育部春晖计划合作科研资助项目(202200681) （202200681）
河南省高等学校重点科研资助项目(21A910001) （21A910001）
