北京大学学报（医学版）2024，Vol.56Issue(4)：680-686,7.DOI:10.19723/j.issn.1671-167X.2024.04.022
阴茎海绵体注射试验对阴茎血管功能影响的回顾性研究
Retrospective study on the impact of penile corpus cavernosum injection test on pe-nile vascular function
摘要
Abstract
Objective:To investigate the impact of age,various hormonal levels,and biochemical markers on penile cavernous body vascular function in patients with erectile dysfunction(ED).Me-thods:A retrospective analysis of clinical data from male patients with ED who underwent color duplex Doppler ultrasonography(CDDU)and intracavernosal injection test(ICI)at the Reproductive Medicine Center of Peking University Third Hospital from January 2020 to August 2023.Data were managed and processed using SPSS 29.0,and a multivariable Logistic regression analysis was conducted.Results:A total of 700 ED patients were included,with 380 showing negative ICI results and 320 positive.In the study,84 patients had a peak systolic velocity(PSV)＜25 cm/s,while 616 had PSV ≥ 25 cm/s;202 patients had end-diastolic velocity(EDV)＞5 cm/s,and 498 had EDV ≤5 cm/s.264 patients had ab-normal PSV and/or EDV results,and 436 had normal results for both.Patients with vascular ED had sig-nificantly lower estrogen levels(t=-3.546,P＜0.001),lower testosterone levels(t=-2.089,P=0.037),and a higher rate of hyperglycemia(x2=12.772,P=0.002)compared with those with non-vascular ED.The patients with arterial ED were older(t=3.953,P＜0.001),had a higher rate of hyperglycemia(x2=9.518,P=0.009),and a higher estrogen/testosterone ratio(t=2.330,P=0.020)compared with those with non-arterial ED.The patients with mixed arteriovenous ED had higher age(t=3.567,P＜0.001),lower testosterone levels(t=-2.288,P=0.022),a higher rate of hyperglycemia(x2=12.877,P=0.002),and a larger estrogen/testosterone ratio(t=2.096,P=0.037)compared with those with normal findings.Multifactorial Logistic regression analysis indicated that higher levels of estrogen were a protective factor for vascular ED(OR=1.009,95％CI:1.004-1.014),and glucose 7.0 mmol/L was a risk factor(OR=0.381,95％CI:0.219-0.661).Older age was a risk factor for arte-rial ED(OR=0.960,95％CI:0.938-0.982).Additionally,older age(OR=0.976,95％CI:0.958-0.993)and glucose levels of 5.6-6.9 mmol/L(OR=0.591,95％CI:0.399-0.876)were also risk fac-tors for mixed arterio-venous ED.Conclusion:Hyperglycemia and aging may impair penile cavernous body vascular function,while higher levels of estrogen may have a protective effect on it.关键词
勃起功能障碍/彩色双频多普勒超声/阴茎海绵体注射/血管/危险因素Key words
Erectile dysfunction/Color duplex Doppler ultrasonography/Intracavernosal injection/Blood vessels/Risk factors分类
医药卫生引用本文复制引用
陈延,姜辉,林浩成,李况蒙,洪锴,张树栋,程建星,郑仲杰,唐文豪,赵连明,张海涛..阴茎海绵体注射试验对阴茎血管功能影响的回顾性研究[J].北京大学学报（医学版）,2024,56(4):680-686,7.基金项目
国家自然科学基金(82371633)和北京大学临床科学家计划专项-中央高校基本科研业务费(BMU2023PYJ H012)Supported by the National Natural Science Foundation of China(82371633)and the Fundamental Research Funds for the Central Universities:Peking University Clini-cal Scientist Program(BMU2023PYJ H012) （82371633）
