川北医学院学报2024，Vol.39Issue(7)：865-869,912,6.DOI:10.3969/j.issn.1005-3697.2024.07.001
彝医药金薄清咽颗粒制备工艺及对慢性咽炎模型大鼠的疗效机制
Yi nationality medicine JinBo QingYan Granules:Preparation process and its therapeutic mechanism on chronic pharyngitis model rats
摘要
Abstract
Objective:To study the preparation technology of Yi medicine JinBo Qingyan Granules(JBQYG)and its therapeutic mechanism on chronic pharyngitis(CP)model rats.Methods:Selected the optimal excipients for molding process screening and HPLC analysis.JBQYG was used to intervene CP rats.The morphology,pathology,transcription factor p65(NF-κB p65)protein expression,inflammation and oxidation status of throat levels were detected.Results:The optimal excipient was lactose,and the molding technology was as follows:pure extract:lactose 8∶1,ethanol concentration 95%,ethanol dosage 10%,paeoniflorin was stable.JBQYG decreased the phosphorylation level of NF-κB p65 protein in throat of CP rats and increased the total antioxidant capacity,reversed the inflammation and oxidative stress induced by ammonia,thus improved the appearance and pathology of throat.JBQYG improved the oxidative stress more effectively than aspirin,the difference was statistically significant(P＜0.05).Conclusion:The formulation preparation process determined through the research is reasonable.JBQYG can improve the inflammatory and oxidative state,appearance and pathology of CP by decreasing the phosphorylation level of NF-κB p65 and increasing the total antioxidant capacity.关键词
金薄清咽颗粒/成型工艺/慢性咽炎/氧化应激/转录因子p65/炎性反应/彝族药物Key words
JinBo QingYan Granule/Molding technology/Chronic pharyngitis/Oxidative stress/Transcription factor p65/Inflam-matory reaction/Yi nationality medicine分类
医药卫生引用本文复制引用
吴伟,吴俊汐,耿福昌,刘彬,杨元素,赵珊,马跃,张春兰..彝医药金薄清咽颗粒制备工艺及对慢性咽炎模型大鼠的疗效机制[J].川北医学院学报,2024,39(7):865-869,912,6.基金项目
四川省中医药管理局中医药科研专项(2021MS036) （2021MS036）
