血清高敏C反应蛋白/前白蛋白比值与急性ST段抬高型心肌梗死患者PCI术后冠状动脉无复流的相关性OACSTPCD

Objective:To investigate the predictive value of high-sensitivity C-reactive protein/prealbumin(hs-CRP/PA)ratio for coronary no-reflow after PCI in patients with acute ST-segment elevation myocardial infarction(STEMI).Methods:A total of 98 pa-tients with acute STEMI were selected.The patients were divided into no-reflow group(n=25)and reflow group(n=73)according to the postoperative thrombolysis in myocardial infarction(TIMI)blood flow classification.Before PCI,the levels of serum hs-CRP and PA were detected,and the ratio of hs-CRP/PA was calculated.Logistic regression model was used to analyze the influencing factors of coro-nary no-reflow after PCI,and the receiver operating characteristic(ROC)curve was used to evaluate the predictive efficacy of hs-CRP/PA ratio on coronary no-reflow.Results:Compared with the reflow group,the serum PA level in the no-reflow group was lower(P＜0.05),and the LVEF,cTnI,BNP,hs-CRP and hs-CRP/PA ratio were higher(P＜0.05).Logistic regression analysis showed that preoperative LVEF,hs-CRP,PA and hs-CRP/PA ratio were independent related factors of coronary no-reflow after PCI(P＜0.05).ROC curve analysis showed that the AUC of hs-CRP/PA ratio in predicting coronary no-reflow after PCI in patients with acute STEMI was 0.802,which was higher than that of hs-CRP(AUC was 0.707)and PA(AUC was 0.642,P＜0.05).When the cutoff value was greater than 28.5,the sensitivity of hs-CRP/PA ratio was 88.0%and the specificity was 68.5%.Conclusion:Preoperative serum hs-CRP/PA ratio is an independent predictor of postoperative coronary no-reflow in patients with acute STEMI.Compared with a single in-dicator,it can better identify patients with high risk of coronary no-reflow.