川北医学院学报2024，Vol.39Issue(7)：920-923,4.DOI:10.3969/j.issn.1005-3697.2024.07.013
小剂量艾司氯胺酮对腹腔镜胆囊切除术患者全麻苏醒期躁动及炎症应激反应的影响
Effect of low-dose esketamine on agitation and inflammatory stress re-sponse in patients undergoing laparoscopic cholecystectomy during general anesthesia recovery period
摘要
Abstract
Objective:To investigate the effects of low-dose esketamine on emergence agitation(EA)and inflammatory response in patients undergoing laparoscopic cholecystectomy(LC)during general anesthesia recovery period.Methods:A total of 110 patients undergoing LC were divided into control group and esketamine group according to the different ways of intervention,with 55 cases in each group.Before anesthesia induction,the esketamine group was injected with 0.25 mg/kg,while the control group was intravenously injected with the same amount of normal saline.The incidence of EA was compared between the two groups.The dosage of anesthetics during operation,Ramsay sedation score during recovery period and visual analogue scale(VAS)after extubation were recorded and compared between the two groups.The levels of serum interleukin-6(IL-6)and interleukin-8(IL-8)were measured at the time of en-tering the operating room(T0),at the end of operation(T1),at the time of extubation(T2)and 15 min after extubation(T3),and the hospitalization time and incidence of adverse reactions were compared between the two groups.Results:Compared with the control group,the incidence of EA in the esketamine group was decreased(P＜0.05),and the severity of agitation was reduced(P＜0.05).The dosage of remifentanil in the esketamine group was less than that in the control group(P＜0.05),.the Ramsay score of the esket-amine group during the recovery period was higher than that of the control group(P＜0.05),and the VAS score decreased at 10 min after extubation was lower than that of the control group(P＜0.05).Compared with the control group,at T1,T2 and T3,the serum lev-els of IL-6 and IL-8 in the esketamine group decreased(P＜0.05).The postoperative hospital stay in the esketamine group was shorter comparing with the control group(P＜0.05),and there was no significant difference in postoperative adverse reactions between the two groups(P>0.05).Conclusion:Low-dose esketamine can effectively prevent the occurrence of EA in LC patients,which may be relat-ed to reducing postoperative pain and inhibiting inflammatory response.关键词
苏醒期躁动/腹腔镜胆囊切除术/艾司氯胺酮/疼痛/炎症反应Key words
Emergence agitation/Laparoscopic cholecystectomy/Esketamine/Pain/Inflammatory response分类
医药卫生引用本文复制引用
闻萍,周先明..小剂量艾司氯胺酮对腹腔镜胆囊切除术患者全麻苏醒期躁动及炎症应激反应的影响[J].川北医学院学报,2024,39(7):920-923,4.基金项目
安徽省卫生健康委科研项目(AHWJ2021b131) （AHWJ2021b131）
