川北医学院学报2024，Vol.39Issue(8)：1009-1013,5.DOI:10.3969/j.issn.1005-3697.2024.08.001
高血压、心房颤动与阿尔兹海默症风险:一项孟德尔随机研究
Association between high blood pressure,atrial fibrillation,and Alzheimer's disease:a Mendelian randomized study
摘要
Abstract
Objective:To evaluate the causal relationship between high blood pressure,atrial fibrillation,and Alzheimer's disease using a dual sample Mendelian randomization of genetic variation,in order to avoid the limitations of observational studies.Methods:The data comes from the IEU Large high blood pressure(HBP)Dataset,atrial fibrillation(AF)Dataset,and Alzheimer's disease(AD).The causal effects were estimated using inverse variance weighting(IVW),mendelian randomization(MR)Egger,weighted median,Simple mode,and Weighted mode.Sensitivity analysis was conducted using Cochran's Q test and MR Egger intercept test.Re-sults:There was no significant association between genetically predicted HBP and the risk of AD(OR=0.89,95％CI:0.53～1.49,P=0.58),MR Egger did not find evidence of genetic pleiotropy(intercept=0.007,P=0.39).There was no association between AF and the risk of AD(OR=1.04,95％CI:0.97～1.10,P=0.75),MR Egger did not reveal evidence of genetic pleiotropy(intercept=0.002,P=0.63).Conclusion:Mendelian randomization analysis did not find a causal relationship between HBP,AF and AD.关键词
HBP/AF/AD/孟德尔随机化研究/单核苷酸多态性Key words
High blood pressure/Atrial fibrillation/Alzheimer's disease/Mendelian randomization/Single nucleotide polymor-phisms分类
医药卫生引用本文复制引用
蒲珊珊,朱小敏,卓桂锋,陈炜,吴林..高血压、心房颤动与阿尔兹海默症风险:一项孟德尔随机研究[J].川北医学院学报,2024,39(8):1009-1013,5.基金项目
国家自然科学基金项目(No.82160885 （）
No.82060844) （）
国家中医药管理局高水平重点学科-中医内科学项目(ZYYZDXK-2023166) （ZYYZDXK-2023166）
广西壮族自治区自然科学基金面上项目(No.2022GXNSFAA035461) （No.2022GXNSFAA035461）
广西壮族自治区中医基础研究重点实验室项目(KJT15007) （KJT15007）
广西中医药大学"歧黄工程"高层次人才团队项目(202410) （202410）
