川北医学院学报2024，Vol.39Issue(8)：1049-1051,1055,4.DOI:10.3969/j.issn.1005-3697.2024.08.010
依特卡肽治疗糖尿病肾病维持性血液透析继发甲状旁腺功能亢进的疗效观察
Efficacy of etelcalcetide in the treating of secondary hyperparathyroidism to maintenance hemodialysis in diabetic nephropathy
摘要
Abstract
Objective:To explore the effect of etelcalcetide on secondary hyperparathyroidism(SHPT)in maintenance hemodi-alysis(MHD)of diabetic nephropathy.Methods:92 patients with SHPT caused by diabetic nephropathy MHD were divided into study group(46 cases)and control group(46 cases)by using different therapeutic drugs.The study group was treated with etelcalcetide,while the control group was given cinacalcet,and both groups were treated continuously for 3 months.The differences in parathyroid in-dicators,biochemical indices,fibroblast growth factor 23(FGF23)levels,bone metabolism indicators before and after treatment were compared between the two groups.The incidence of adverse reactions of the two groups was recorded.Results:After treatment,the thy-roid indicators,serum indicators,FGF23 levels and bone metabolism indicators of patients were decreased(P＜0.05),and the above in-dicators in study group were lower(P＜0.05).The incidence rates of adverse reactions in study group were lower than those in control group(P＜0.05).Conclusion:Etelcalcetide can effectively improve the parathyroid function in patients with SHPT secondary to MHD of diabetic nephropathy.关键词
糖尿病肾病/维持性血液透析/继发性甲状旁腺功能亢进/甲状腺指标Key words
Diabetic nephropathy/Maintenance hemodialysis/Secondary hyperparathyroidism/Parathyroid indicators分类
医药卫生引用本文复制引用
马世兴,仇琳,王勤超..依特卡肽治疗糖尿病肾病维持性血液透析继发甲状旁腺功能亢进的疗效观察[J].川北医学院学报,2024,39(8):1049-1051,1055,4.基金项目
陕西省社会发展科技攻关项目(2020A089) （2020A089）
